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SAB1408140

Sigma-Aldrich

Anti-TNS4 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(s):

CTEN, FLJ14950, PP14434

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50 μG
CHF 403.00

CHF 403.00

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50 μG
CHF 403.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

CHF 403.00

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~51.8 kDa

species reactivity

human

technique(s)

indirect immunofluorescence: suitable
western blot: 1 μg/mL

NCBI accession no.

BC018706

UniProt accession no.

Q8IZW8

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TNS4(84951)

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This Item
SAB1405316WH0084951M1SAB5500089
Anti-TNS4 antibody produced in mouse purified immunoglobulin, buffered aqueous solution

SAB1408140

Anti-TNS4 antibody produced in mouse

Monoclonal Anti-TNS4 antibody produced in mouse clone 1C1, purified immunoglobulin, buffered aqueous solution

SAB1405316

Monoclonal Anti-TNS4 antibody produced in mouse

Monoclonal Anti-TNS4 antibody produced in mouse clone 3B8, purified immunoglobulin, buffered aqueous solution

WH0084951M1

Monoclonal Anti-TNS4 antibody produced in mouse

Anti-C-TEN antibody, Rabbit monoclonal recombinant, expressed in proprietary host, clone SP83, affinity isolated antibody

SAB5500089

Anti-C-TEN antibody, Rabbit monoclonal

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

clone

polyclonal

clone

1C1, monoclonal

clone

3B8, monoclonal

clone

SP83, monoclonal

technique(s)

indirect immunofluorescence: suitable, western blot: 1 μg/mL

technique(s)

indirect ELISA: suitable, western blot: 1-5 μg/mL

technique(s)

immunofluorescence: suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL

technique(s)

immunohistochemistry: 1:100

General description

Mouse polyclonal antibody raised against a full-length human TNS4 protein.
TNS4 (Tensin 4) is a signaling molecule localized in the prostate and placenta. It is a member of the TENSIN gene family. It has a Src homology 2 and phosphotyrosine-binding domains. Its expression has been observed in the early progression of melanoma cells.

Immunogen

TNS4 (AAH18706.1, 1 a.a. ~ 480 a.a) full-length human protein.

Sequence
MGSKASSPHGLGSPLVASPRLEKRLGGLAPQRGSRISVLSASPVSDVSYMFGSSQSLLHSSNSSHQSSSRSLESPANSSSSLHSLGSVSLCTRPSDFQAPRNPTLTMGQPRTPHSPPLAKEHASSCPPSITNSMVDIPIVLINGCPEPGSSPPQRTPGHQNSVQPGAASPSNPCPATRSNSQTLSDAPFTTCPEGPARDMQPTMKFVMDTSKYWFKPNITREQAIELLRKEEPGAFVIRDSSSYRGSFGLALKVQEVPASAQSRPGEDSNDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQHSIMALALPCKLTIPQRELGGADGASDSTDSPASCQKKSAGCHTLYLSSVSVETLTGALAVQKAISTTFERDILPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLTTLRFCGMDPEQRKWQKYCKPSWIFGFVAKSQTEPQENVCHLFAEYDMVQPASQVIGLVTALLQDAERM

Application

Anti-TNS4 antibody produced in mouse is suitable for indirect immunofluorescence and western blot.

Biochem/physiol Actions

TNS4 (Tensin 4) is mainly involved in cell migration activity. It exhibits oncogenic property in colonic, breast, lung, and gastric cancers. In studies, its overexpression has been reported in the pancreatic cancer cells. In pancreatic cancer cells, TNS4 promotes colony formation and cell motility. It has been predicted that TNS4 could be a prognostic marker for primary melanoma.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
09005

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Cecilia Sjoestroem et al.
PloS one, 8(11), e80492-e80492 (2013-11-19)
C-terminal tensin-like protein (Cten) is a focal adhesion protein originally identified as a tumor suppressor in prostate cancer. It has since been found to be overexpressed and function as an oncogene in numerous other cancers, but the expression status of
Saleh Al-Ghamdi et al.
Pancreas, 42(1), 135-140 (2012-07-04)
C-terminal tensin-like gene (CTEN, also known as TNS4) localizes to focal adhesions and is reported to function as an oncogene in colonic, breast, lung, and gastric cancers. Its role in pancreatic cancer is unknown and was thus investigated in this
Abdulkader Albasri et al.
Breast cancer research and treatment, 126(1), 47-54 (2010-04-15)
C-terminal tensin-like (CTEN) gene is a member of the TENSIN gene family, involved in cell migration and localised at focal adhesion sites. This study was designed to explore the prevalence and clinical significance of CTEN expression in a large and

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