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SAB1306806

Sigma-Aldrich

ANTI-MSL1 (CENTER) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

MSL1, MSL1L1, Male-specific lethal 1 homolog, Male-specific lethal 1-like 1, Male-specific lethal-1 homolog 1

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400 μL
CHF 326.00

CHF 326.00

Estimated to ship on11 May 2025

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400 μL
CHF 326.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

CHF 326.00

Estimated to ship on11 May 2025

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

67128 Da

species reactivity

human

technique(s)

western blot: 1:1000

NCBI accession no.

NP_001012241.1

UniProt accession no.

Q68DK7

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MSL1(339287)

General description

The gene MSL1 (male specific lethal 1 homolog) encodes a histone acetyl transferase-associated protein that spans a length of 614 amino acid residues. It does not contain any globular domains.

Biochem/physiol Actions

The gene MSL1 (male specific lethal 1 homolog) encodes a protein associated with mammalian MOF (male-absent-on-the-first)-MSL (male-specific-lethal) complex that is also referred to as the ‘dosage compensation complex′ (DCC). This complex is involved in the equalization of X-chromosomal genes expression between males and females. It is found to form a complex with Nupr1 (nuclear protein 1) in the nucleus in response to DNA-damage and may be involved in DNA repair activity. MSL1 protein is found to regulate acetylation of global histone H4 via its interaction with KAT8 (lysine acetyltransferase 8).

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SA110804BB

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David Aguado-Llera et al.
PloS one, 8(10), e78101-e78101 (2013-11-10)
The stress protein Nupr1 is a highly basic, multifunctional, intrinsically disordered protein (IDP). MSL1 is a histone acetyl transferase-associated protein, known to intervene in the dosage compensation complex (DCC). In this work, we show that both Nupr1 and MSL1 proteins
Ruslan I Dmitriev et al.
Journal of cellular biochemistry, 115(11), 1967-1973 (2014-06-11)
MSL1 protein regulates global histone H4 acetylation at residue K16 in stem and cancer cells, through interaction with KAT8. The functional significance of mammalian MSL1 isoforms, involved in various protein interactions, is poorly understood. We report the identification of a

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