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S7023

Sigma-Aldrich

Sera human

frozen liquid

Synonym(s):

Human Blood Serum, Human Serum

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50 ML
CHF 179.00
100 ML
CHF 494.00

CHF 179.00


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50 ML
CHF 179.00
100 ML
CHF 494.00

About This Item

UNSPSC Code:
12352207
NACRES:
NA.71
biological source:
human
origin:
USA origin
form:
frozen liquid
shipped in:
dry ice

CHF 179.00


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biological source

human

Quality Level

form

frozen liquid

origin

USA origin

shipped in

dry ice

storage temp.

−20°C

General description

The serum is the fluid from plasma devoid of fibrinogen, prothrombin, and other clotting factors. It contains various plasma proteins, amino acids, polypeptides, growth factors, fat, carbohydrates, nucleic acid derivatives, hormones, inorganic minerals, and vitamins.

Application

Sera human has been used:
  • to prepare the antigen standards for the validation assay of multiple-biomarker detection
  • as a quality check (QC) sample to optimize the experimental workflow
  • as a control in immunoproteomics assay

Biochem/physiol Actions

Human serum is used as a cell culture supplement. It maintains physiological balance by stimulating or inhibiting cell growth. It is known to have an inhibitory action on endogenous and exogenous enzymes.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Kuiama Lewandowski et al.
The Journal of molecular diagnostics : JMD, 19(2), 303-312 (2017-01-04)
Extraction of viral RNA and the storage of sample material are extremely important factors in the detection and whole genome sequencing (WGS) of viral pathogens. Although PCR-based detection methods focus on small amplicons, viral WGS applications require RNA of high
Sílvia A Sousa et al.
Vaccines, 8(3) (2020-09-10)
Infections by the Burkholderia cepacia complex (Bcc) remain seriously life threatening to cystic fibrosis (CF) patients, and no effective eradication is available. A vaccine to protect patients against Bcc infections is a highly attractive therapeutic option, but none is available.
Qin Fu et al.
Methods in molecular biology (Clifton, N.J.), 357, 365-371 (2006-12-19)
Serum is a readily available source for diagnostic assays, but the identification of disease-specific serum biomarkers has been impeded by the dominance of human serum albumin (HSA) and immunoglobulin G (IgG) in the serum proteome. Therefore, in order to observe
Josep Villanueva et al.
Nature protocols, 1(2), 880-891 (2007-04-05)
Blood is a convenient source of biomarkers. Readily obtainable, it immerses most tissues in the body and is therefore likely to contain cell-derived proteins and peptides that may provide information about various biological processes. Serum proteome and peptidome profiling--using mass
Amandine Buffet et al.
Proceedings. Biological sciences, 288(1946), 20202876-20202876 (2021-03-04)
The fitness cost associated with the production of bacterial capsules is considered to be offset by the protection provided by these extracellular structures against biotic aggressions or abiotic stress. However, it is unknown if the capsule contributes to fitness in

Questions

  1. Could you provide more details about the processing method used to prepare frozen human serum? Specifically, how are the sera collected, pooled, and processed from whole blood? Additionally, I'm interested in learning about any quality control (QC) testing conducted beyond testing for infectious agents.

    1 answer
    1. The Technical Service department has collected historical data from various sources on the sera supplied to us from licensed donor centers in the United States. The sera, pooled from multiple normal subjects, is collected from clotted whole blood without additives and is "off the clot" with no azide added. The human serum undergoes testing for HIV and HBSAG by FDA-licensed labs. The donor pools can consist of up to 200 donors and are sterile filtered through a 0.22 micron filter. The product is not manufactured under GMP and is intended for laboratory or research use only. It is produced under ISO 9001 and undergoes sterility testing according to USP guidelines. For more information on the quality, please refer to the provided link.

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