S5009
[D-Pro4, D-Trp7,9]-substance fragment 4-11
≥97% (HPLC)
Synonym(s):
D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2
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Assay
≥97% (HPLC)
storage temp.
−20°C
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Antagonists of substance P.
European journal of pharmacology, 77(2-3), 205-206 (1982-01-22)
Journal of medicinal chemistry, 25(11), 1313-1316 (1982-11-01)
Several substance P analogues containing various D-amino acid modifications have been synthesized by the solid-phase procedure, detached from the solid support by ammonolysis, and purified by gel filtration combined with reversed-phase chromatography. Three compounds were fair to very potent competitive
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