Rattin or RNR2 (RNA, ribosomal 45S cluster 2) is a subunit of the ribonucleoside diphosphate reductase. It is located on chromosome 14p12.
Immunogen
peptide corresponding to the rattin peptide (amino acids 20-35), which is not in the conserved region to humanin.
Biochem/physiol Actions
Rattin or RNR2 (RNA, ribosomal 45S cluster 2) helps in the synthesis of nucleotide precursors. It is responsible for the formation of the deoxyribonucleotides required for DNA synthesis. It is an important cofactor of HIV-1, that induces reverse transcription in MDMs (monocyte-derived macrophages).
Physical form
Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
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Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts
Kuroiwa Y, et al.
Nature Biotechnology, 18(10), 1086-1090 (2000)
Application of yeast cells transformed with GFP expression constructs containing the RAD54 or RNR2 promoter as a test for the genotoxic potential of chemical substances
Afanassiev V, et al.
Mutation Research, 464(2), 297-308 (2000)
Identification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it
Elledge SJ and Davis RW, et al.
Molecular and Cellular Biology, 9(12), 5373-5386 (1989)
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