PZ0339

PF-06683324

≥98% (HPLC)

• Synonym(s): 2-((3R,4S)-3-Fluoro-1-(2-(4-(trifluoromethoxy)phenyl)acetyl)piperidin-4-yloxy)-5-(1-methyl-1H-imidazol-4-yl)nicotinamide, 2-[[(3R,4S)-3-Fluoro-1-[[4-(trifluoromethoxy)phenyl]acetyl]piperidin-4-yl]oxy]-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide, PF06683324
• Empirical Formula (Hill Notation): C₂₄H₂₃F₄N₅O₄
• CAS Number: 1799788-94-5
• Molecular Weight: 521.46
• UNSPSC Code: 12352200
• PubChem Substance ID: 329823848
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 30 mg/mL, clear
• storage temp.: room temp
• SMILES string: O=C(CC1=CC=C(OC(F)(F)F)C=C1)N2C[C@@H](F)[C@@H](OC3=C(C(N)=O)C=C(C4=CN(C)C=N4)C=N3)CC2
• InChI: 1S/C24H23F4N5O4/c1-32-12-19(31-13-32)15-9-17(22(29)35)23(30-10-15)36-20-6-7-33(11-18(20)25)21(34)8-14-2-4-16(5-3-14)37-24(26,27)28/h2-5,9-10,12-13,18,20H,6-8,11H2,1H3,(H2,29,35)/t18-,20+/m1/s1
• InChI key: XJIIVPVOGYFVME-QUCCMNQESA-N

Description

Biochem/physiol Actions

PF-0668324 is pan tropomyosin-related kinase (Trk) inhibitor.

Other Notes

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable