PLA0253

Rabbit anti-NPM1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• Synonym(s): B23, NPM, member 1, nucleolar phosphoprotein B23, nucleolar protein NO38, nucleophosmin/nucleoplasmin family, numatrin, testicular tissue protein Li 128
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• grade: Powered by Bethyl Laboratories, Inc.
• species reactivity: human
• technique(s): immunoprecipitation (IP): 5-10 μg/mg
• accession no.: NP_002511.1
• UniProt accession no.: P06748
• shipped in: wet ice
• storage temp.: 2-8°C
• Gene Information: rabbit ... NPM1(4869)

Description

Immunogen

The epitope recognized by PLA0253 maps to a region between residue 200 and 250 of human nucleophosmin using the numbering given in entry NP_002511.1 (GeneID 4869).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

Nucleophosmin (NPM1) is involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors TP53/p53 and ARF. It associates with nucleolar ribonucleoprotein structures and binds single-stranded nucleic acids. NPM1 binds ribosomes presumably to drive ribosome nuclear export. Chromosomal aberrations involving NPM1 have been identified in several types of leukemia [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P06748].

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable