Skip to Content
Merck
All Photos(1)

Key Documents

P5806

Sigma-Aldrich

Pasteurella multocida toxin

lyophilized powder

Synonym(s):

PMT

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

CAS Number:
129876-91-1
MDL number:
MFCD00131803
UNSPSC Code:
12352200
NACRES:
NA.77

sterility

sterile-filtered

Quality Level

200

form

lyophilized powder

packaging

vial of 50 μg toxin (Also contains 10 mM Tris, 0.1 M NaCl, and 0.1% sucrose, pH 8.3.)

storage temp.

−20°C

Biochem/physiol Actions

Pasteurella multocida toxin (PMT) is a bacterial protein toxin produced by few P. multocida serotype A and D strains. It acts as an effective mitogen in numerous cell types in vitro. PMT inhibits osteoblast differentiation by activating the Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK) pathway. Infections of PMT cause atrophic rhinitis in pigs and by local dermatonecrosis, respiratory disease in cattle and rabbits. PMT is also a pathogenic agent of dermatonecrosis and bacteremia in humans.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The Pasteurella multocida toxin is encoded within a lysogenic bacteriophage
Pullinger GD, et al.
Molecular Microbiology, 51(1), 255-269 (2004)
Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and-independent mechanisms involvement of Gq but not G11
Zywietz A, et al.
The Journal of biological chemistry, 276(6) (2001)
Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation
Harmey D, et al.
Journal of Bone and Mineral Research, 19(4), 661-670 (2004)

Articles

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service