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P4005

Sigma-Aldrich

Protamine

solid

Synonym(s):

Protamine

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250 MG
CHF 131.00
1 G
CHF 309.00
5 G
CHF 995.00

CHF 131.00

Estimated to ship on16 April 2025

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250 MG
CHF 131.00
1 G
CHF 309.00
5 G
CHF 995.00

About This Item

CAS Number:
9012-00-4
EC Number:
232-726-0
MDL number:
MFCD00132089
UNSPSC Code:
12352202
NACRES:
NA.77

CHF 131.00

Estimated to ship on16 April 2025

Product Name

Protamine from salmon, Grade IV, Histone, free(Millon test)

biological source

fish (salmon)

Quality Level

200

type

Grade IV

form

solid

impurities

Histone, free (Millon test)

solubility

H2O: soluble, clear to slightly hazy, colorless to faintly yellow

storage temp.

−20°C

General description

Protamines are proteins rich in cysteine and arginine.[1] It possesses many phosphorylation sites. Salmon fish contains around 15 genes encoding protamine.[2] It is found to be localized to the sperm head.[3]

Application

Protamine from salmon has been used to avoid in vitro AT complex formation in samples from dogs pre-treated with heparin.[4] It has also been used to study the influences of external potential on adsorption of various proteins to a metal surface.[5]

Biochem/physiol Actions

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.[6]
Protamines are found to displace histones in DNA during spermatogenesis[1] in animals and plants.[2] Protamine is useful as a heparin neutralizer during heart surgery, dialysis and in many other clinical procedures.[3]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000344271
111M7405V
100M7405V
100M7405
039K7435

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Adsorption characteristics of various proteins on a metal surface in the presence of an external electric potential
Htwe EE, et al.
Colloids and Surfaces, B: Biointerfaces, 262-268 (2018)
Ryan B McMillan et al.
Biophysical journal, 120(12), 2521-2531 (2021-05-24)
DNA looping plays an important role in cells in both regulating and protecting the genome. Often, studies of looping focus on looping by prokaryotic transcription factors like lac repressor or by structural maintenance of chromosomes proteins such as condensin. Here
Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin
Petersen LC, et al.
British Journal of Haematology, 152(1), 99-107 (2011)
Alicia Roque et al.
Nucleic acids research, 32(20), 6111-6119 (2004-11-25)
Histone H1 preferentially binds and aggregates scaffold-associated regions (SARs) via the numerous homopolymeric oligo(dA).oligo(dT) tracts present within these sequences. Here we show that the mammalian somatic subtypes H1a,b,c,d,e and H1 degrees and the male germline-specific subtype H1t, all preferentially bind
Obinna A Ukogu et al.
Nucleic acids research, 48(11), 6108-6119 (2020-05-12)
Protamine proteins dramatically condense DNA in sperm to almost crystalline packing levels. Here, we measure the first step in the in vitro pathway, the folding of DNA into a single loop. Current models for DNA loop formation are one-step, all-or-nothing
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