M6020

D-(+)-Mannose

powder, BioReagent, suitable for cell culture

• Synonym(s): D-Mannopyranose
• Empirical Formula (Hill Notation): C₆H₁₂O₆
• CAS Number: 3458-28-4
• Molecular Weight: 180.16
• Beilstein: 1564373
• EC Number: 222-392-4
• MDL number: MFCD00064122
• UNSPSC Code: 12352201
• PubChem Substance ID: 24897068
• NACRES: NA.75

Properties

• biological source: plant (Spruce, Birch or Beech Wood, Glucose)
• product line: BioReagent
• Assay: ≥99%
• form: powder
• technique(s): cell culture | mammalian: suitable
• mp: 133-140 °C (lit.)
• solubility: H₂O: 50 mg/mL
• application(s): agriculture
• SMILES string: OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6?/m1/s1
• InChI key: WQZGKKKJIJFFOK-QTVWNMPRSA-N

Description

General description

Mannose is an aldohexose carbohydrate. It is isomer of glucose with varying C2 position configuration.[1] Majority of mannose is synthesised from its epimer glucose.[2] It is part of the glycans present in endoplasmic reticulum (ER)/Golgi.[2]

Application

D-(+)-Mannose has been used:

• as a reference standard in monosaccharide analysis and quantification from sea squirts Ascidiella aspersa[3]
• as a medium component for the selection of P898012 sorgum seeds transfected with Agrobacterium[4]
• in segmented filamentous bacterium (SFB) medium supplement for culturing human cell lines[5]

Mannose is an aldohexose carbohydrate. This product may be used to study the effects of exogenous mannose on in vitro processes such as glycosylation.

Biochem/physiol Actions

Mannose may be used to study the effects of exogenous mannose on in vitro processes such as glycosylation. cis-Golgi glycoproteins have high mannose and are prone to Endoglycosidase H or peptide N-glycosidase (N-glycanase) digestion.[6]

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves