I8904
Insulin-like Growth Factor-II from mouse
IGF-II, recombinant, expressed in E. coli, lyophilized powder
Synonym(s):
IGF-II
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Recommended Products
biological source
mouse
recombinant
expressed in E. coli
Assay
>97% (SDS-PAGE)
form
lyophilized powder
quality
endotoxin tested
mol wt
~7.4 kDa
packaging
pkg of 5X50 μg
pkg of 50 μg
impurities
<1.0EUper1mg (LAL test)
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... IGF2(16002) , Igf2(16002)
General description
Recombinant Mouse IGF-II is produced from a DNA sequence encoding the mature IGF-II protein. Mouse IGF-II, a 67 amino acid protein, has a predicted molecular matrix of ~7.4 kDa. Mouse and human IGF-II share 91% sequence homology. Insulin-like growth factor II (also known as multiplication stimulating activity or MSA) and insulin-like growth factor I (IGF-I) belong to the family of insulin-like growth factors, which are structurally homologous to proinsulin. Mature IGF-I and IGF-II are highly conserved and share ~70% amino acid sequence identity. They have autocrine, paracrine, and endocrine functions.
Biochem/physiol Actions
Insulin-like growth factor II (IGF-II) is a potent mitogenic growth factor that mediates growth-promoting activities in embryonic development. IGF-II binds the IGF-II receptor with high affinity. IGF-I and IGF II are expressed in many tissues and cell types. IGF-II is mitogenic for a variety of cultured cells including human or chicken fibroblasts, mouse 3T3 cells, normal rat kidney.
Physical form
Lyophilized from a 0.2 μm filtered solution of 30% acetonitrile and 0.1% of TFA.
Analysis Note
The biological activity is measured in a serum-free cell proliferation assay using the human breast carcinoma cell line MCF-7.
related product
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Biyun Qian et al.
Oncology reports, 25(1), 203-213 (2010-11-27)
High expression of insulin-like growth factor-II (IGF-II) in epithelial ovarian cancer is associated with aggressive disease and poor prognosis. IGF-II transcription is initiated from multiple promoters. Promoter-specific expression is regulated by DNA methylation, which is often dysregulated in cancer. Here
S D O'Dell et al.
The international journal of biochemistry & cell biology, 30(7), 767-771 (1998-09-02)
Insulin-like growth factor II (IGF-II) plays a key role in mammalian growth, influencing foetal cell division and differentiation and possibly metabolic regulation. The mature 67 amino acid peptide shares sequence homology with both insulin and IGF-I. The liver is the
Shuo Chen et al.
Cell reports, 32(6), 108007-108007 (2020-08-14)
Stem cell niches provide a microenvironment to support the self-renewal and multi-lineage differentiation of stem cells. Cell-cell interactions within the niche are essential for maintaining tissue homeostasis. However, the niche cells supporting mesenchymal stem cells (MSCs) are largely unknown. Using
Articles
Insulin-like Growth Factors (IGF)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service