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H8004

Sigma-Aldrich

16α-Hydroxyestrone

≥99% (HPLC)

Synonym(s):

1,3,5(10)-Estratriene-3,16α-diol-17-one, 16α-3,16-Dihydroxyestra-1,3,5(10)-trien-17-one

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About This Item

Empirical Formula (Hill Notation):
C18H22O3
CAS Number:
566-76-7
Molecular Weight:
286.37
MDL number:
MFCD00870436
UNSPSC Code:
12352200
PubChem Substance ID:
24895817

Assay

≥99% (HPLC)
~95% (TLC)

SMILES string

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1C[C@@H](O)C2=O

InChI

1S/C18H22O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-16,19-20H,2,4,6-7,9H2,1H3/t13-,14-,15+,16+,18-/m0/s1

InChI key

WPOCIZJTELRQMF-UJHHCITNSA-N

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Product No.
Description
Pricing

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H351,H360D,H362

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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G Maskarinec et al.
European journal of clinical nutrition, 66(9), 1044-1049 (2012-06-21)
Soy consumption may protect against breast cancer through modification of estrogen metabolism. We examined the effect of soy foods on urinary estrogens and the 2-hydroxy (OH)/16α-OH estrone (E(1)) ratio in two dietary interventions with premenopausal women. The Breast, Estrogens, And
MaryFran R Sowers et al.
The Journal of nutrition, 136(6), 1588-1595 (2006-05-17)
Diet and lifestyle factors, body size, and smoking behavior may influence estrogen metabolism, but the nature of these relations may vary according to race/ethnic groups. We evaluated the association of lifestyle factors with estrogen metabolites 2-hydroxyestrone (2-OHE1) and 16alpha-hydroxyestrone (16alpha-OHE1)
Yukiko Morimoto et al.
Nutrition and cancer, 64(2), 307-314 (2012-02-02)
One of the hypothesized protective mechanisms of soy against breast cancer involves changes in estrogen metabolism to 2-hydroxy (OH) and 16α-OH estrogens. The current analysis examined the effect of soy foods on the 2:16α-OH E(1) ratio among premenopausal women during
Christophe Stavrakakis et al.
Journal of AOAC International, 91(1), 237-246 (2008-04-02)
This paper presents an analytical method applied to the determination of 3 natural steroid hormones, estrone, 17 beta-estradiol, and 16 alpha-hydroxyestrone, and the contraceptive estrogen, 17 alpha-ethynylestradiol, at the sub-ng/L level in water samples [surface water and wastewater treatment plant
Susan R Sturgeon et al.
Nutrition and cancer, 62(2), 175-180 (2010-01-26)
Flaxseed is a rich source of dietary lignans. It has been hypothesized that lignans may decrease breast cancer risk through modulation of endogenous hormone levels. The aim of this study was to determine the effect of flaxseed supplementation on urinary
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