G7261
L-Glutamic acid γ-(7-amido-4-methylcoumarin)
fluorescent amino acid
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About This Item
Empirical Formula (Hill Notation):
C15H16N2O5
CAS Number:
Molecular Weight:
304.30
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
Recommended Products
Assay
≥98% (TLC)
form
powder
technique(s)
HPLC: suitable
color
white to light yellow
storage temp.
−20°C
SMILES string
CC1=CC(=O)Oc2cc(NC(=O)CCC(N)C(O)=O)ccc12
InChI
1S/C15H16N2O5/c1-8-6-14(19)22-12-7-9(2-3-10(8)12)17-13(18)5-4-11(16)15(20)21/h2-3,6-7,11H,4-5,16H2,1H3,(H,17,18)(H,20,21)
InChI key
JPOAPPISZAGCAO-UHFFFAOYSA-N
Biochem/physiol Actions
L-Glutamic acid γ-(7-amido-4-methylcoumarin) (gammaGlu-AMC) may be useful as a fluorogenic substrate for the detection, differentiation or characterization of gamma-glutamyltransferase(s)/transpeptidase(s).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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H D Shine et al.
Neurochemical research, 6(4), 453-463 (1981-04-01)
A new fluorometric assay was developed for the measurement of gamma-glutamyl transpeptidase (gamma-GTP). The assay utilizes as a substrate the synthetic compound 7-gamma-glutamylamido-4-methyl coumarin which is cleaved by gamma-GTP to yield the highly fluorescent product 7-amino-4-methyl coumarin. Optimal excitation and
K D Hammond et al.
Annals of clinical biochemistry, 22 ( Pt 4), 376-380 (1985-07-01)
Activities and isoenzyme patterns of gamma-glutamyl transferase (GGT) were studied in serum samples from fifteen Bantu males suffering from primary hepatoma; the results were compared with those obtained from normal samples. Enzyme activities were significantly higher in hepatoma patients than
L Sacchetti et al.
Clinical chemistry, 34(2), 419-422 (1988-02-01)
In this electrophoretic procedure for measuring isoenzymes of gamma-glutamyltransferase, patterns obtained are highly reproducible and the analytical imprecision (CV) ranges from 1.10% to 6.17%. A cellulose acetate support is used, at 220 V for 40 min. Sharply resolved isoenzyme bands
E Prusak et al.
Clinica chimica acta; international journal of clinical chemistry, 107(1-2), 21-26 (1980-10-23)
Using 7-(gamma-L-glutamyl)-4-methyl-coumarylamide as the fluorogenic substrate a simple and sensitive method for the assay of transferase activity of gamma-glutamyl-transferase in human blood serum and some other biological fluids is described. The substrate was synthesized with a good yield by the
A sensitive fluorimetric assay for gamma-glutamyl transferase.
G D Smith et al.
Analytical biochemistry, 100(1), 136-139 (1979-11-15)
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