E7528
Anti-S1P5, C-Terminal antibody produced in rabbit
~1 mg/mL, fractionated antiserum, buffered aqueous solution
Synonym(s):
Anti-EDG-8, Anti-Endothelial Cell Differentiation Gene 8
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
fractionated antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~42 kDa by SDS-PAGE
species reactivity
human
concentration
~1 mg/mL
technique(s)
western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... S1PR5(53637)
Immunogen
synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-8/S1P5 receptor.
Application
Anti-S1P5, C-Terminal antibody produced in rabbit is suitable for western blotting at a working concentration of 5 to 10 μg/ml using RH7777 cells transfected with full length human EDG-8.
Biochem/physiol Actions
Sphingosine-1-phosphate receptor 5 (S1PR5) is a human gene which encodes a G protein-coupled receptor. It binds to lipid signaling molecule sphingosine 1-phosphate (S1P). S1PR5 regulates NK cell migration and distribution by interacting with sphingosine-1-phosphate (S1P). In brain endothelial cells (ECs), it contributes to optimal barrier formation and maintains immune quiescence of the barrier endothelium. S1PR5 is localized in the centrosome of mammalian cells and may participate in regulating mitosis. It may function as an intracellular target of S1P linked to regulation of mitosis.
Physical form
Supplied in phosphate buffered saline, pH 7.3, containing 0.08% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
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Laura Gillies et al.
Cellular signalling, 21(5), 675-684 (2009-02-13)
We show here that the endogenous sphingosine 1-phosphate 5 receptor (S1P(5), a G protein coupled receptor (GPCR) whose natural ligand is sphingosine 1-phosphate (S1P)) and sphingosine kinases 1 and 2 (SK1 and SK2), which catalyse formation of S1P, are co-localised
Li-Xun Guan et al.
Zhongguo shi yan xue ye xue za zhi, 20(2), 412-415 (2012-05-01)
Natural killer (NK) cells can suppress the development of graft vs host disease (GVHD) while retaining antitumor response in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Sphingosine-1-phosphate receptor 5 (S1PR5) can regulate NK cell migration and distribution in vivo by interacting
Ruben van Doorn et al.
Journal of neuroinflammation, 9, 133-133 (2012-06-22)
The sphingosine 1-phosphate (S1P) receptor modulator FTY720P (Gilenya®) potently reduces relapse rate and lesion activity in the neuroinflammatory disorder multiple sclerosis. Although most of its efficacy has been shown to be related to immunosuppression through the induction of lymphopenia, it
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