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D7571

Sigma-Aldrich

Dimaprit dihydrochloride

≥98% (NMR)

Synonym(s):

Carbamimidothioic acid, 3-(dimethylamino)propyl ester, hydrochloride (1:2), Dimaprit-2HCl

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About This Item

Empirical Formula (Hill Notation):
C6H15N3S · 2HCl
CAS Number:
23256-33-9
Molecular Weight:
234.19
MDL number:
MFCD00069260
UNSPSC Code:
12352200
PubChem Substance ID:
329798854
NACRES:
NA.77

Assay

≥98% (NMR)

form

powder

color

white to off-white

solubility

H2O: ≥50 mg/mL

originator

Roche

storage temp.

−20°C

SMILES string

Cl.Cl.CN(C)CCCSC(N)=N

InChI

1S/C6H15N3S.2ClH/c1-9(2)4-3-5-10-6(7)8;;/h3-5H2,1-2H3,(H3,7,8);2*1H

InChI key

DFWCPLGXFMSUCW-UHFFFAOYSA-N

Biochem/physiol Actions

The histamine H2 receptor influences various cardiovascular responses, including vasodilation and cardiac rhythm, regulates gastric acid secretion, and also plays a role in the immune system by inhibiting antibody production, T cell proliferation and cytokine production. Histamine receptors are members of the GPCR family, and H2 mediates cell signaling via internalization and interaction with the GTPase dynamin.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Esmaeal Tamaddonfard et al.
European journal of pharmacology, 791, 696-702 (2016-10-30)
Histamine receptors are involved in supraspinal modulation of pain. In the present study, we investigated the effects of microinjection of histamine H1, H2 and H3 receptor antagonists and agonists into the ventral posteromedial (VPM) nucleus of the thalamus on two
Parastoo Hashemi et al.
Journal of neurochemistry, 118(5), 749-759 (2011-06-21)
Exploring the mechanisms of serotonin [5-hydroxytryptamine (5-HT)] in the brain requires an in vivo method that combines fast temporal resolution with chemical selectivity. Fast-scan cyclic voltammetry is a technique with sufficient temporal and chemical resolution for probing dynamic 5-HT neurotransmission
Naoto Adachi et al.
European journal of pharmacology, 544(1-3), 181-187 (2006-07-25)
Inflammatory reactions play an important role in ischemia/reperfusion injury in various organs. Since histamine is closely related to inflammatory reactions and immune responses, effects of postischemic administration of histaminergic ligands on ischemia-induced liver injury were examined in rats. Animals were
Hideaki Suzuki et al.
Naunyn-Schmiedeberg's archives of pharmacology, 371(2), 99-106 (2005-03-01)
To elucidate the central roles of histamine receptors in cardiovascular regulatory system, systolic, mean, and diastolic blood pressures (BPs) and heart rate (HR) were examined in conscious H(1) receptor gene knockout (H(1)KO) mice, H(2) receptor gene knockout (H(2)KO) mice, H(1)
Hamid Ghasemi et al.
Pharmacological reports : PR, 69(6), 1393-1401 (2017-11-18)
Histamine and opiate systems contribute to supraspinal processing of pain. In the present study, we investigated the effects of microinjection of histamine and agonists and antagonists of histamine H The thalamic ventral posterolateral nuclei were bilaterally implanted with two guide
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