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C5135

Sigma-Aldrich

Castor Oil, Ethoxylated

pH range 6.0-8.0

Synonym(s):

Cremophor® EL, EL, Macrogolglycerol ricinoleate, PEG-35 castor oil, Polyoxyl-35 castor oil

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500 G
CHF 196.00
1 KG
CHF 357.00

CHF 196.00

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500 G
CHF 196.00
1 KG
CHF 357.00

About This Item

CAS Number:
61791-12-6
MDL number:
MFCD00130879
UNSPSC Code:
12161902
NACRES:
NA.25

CHF 196.00

In StockDetails

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description

non-ionic

Quality Level

200

form

liquid

mol wt

~2500 g/mol

pH range

6.0-8.0

HLB

12 - 14

application(s)

sample preservation

SMILES string

ClCC(OC(=O)N)CCl

InChI

1S/C4H7Cl2NO2/c5-1-3(2-6)9-4(7)8/h3H,1-2H2,(H2,7,8)

InChI key

JMNCUXPHXKHBPY-UHFFFAOYSA-N

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General description

Castor Oil, Ethoxylated is a nonionic solubilizer and emulsifier made by reacting castor oil with ethylene oxide. It is a pale yellow oily liquid that is clear at temperatures above 26°C. It has a faint but characteristic odour.
Castor Oil, Ethoxylated is polyethylene oxide surfactant and is viscous in nature. It has a hydrophobic-lipophilic balance value in the range of 12-14.[1]

Application

Castor Oil, Ethoxylated has been used as a detergent to improve the solubility of dye and to increase the transmembrane permeation.[2][3] It has been used as a vehicle for drug/stimulant delivery in cells.[4][5]

Biochem/physiol Actions

Castor Oil, Ethoxylated is used in lipid-based formulations for drugs and solubilization of cosmetics.[1] Castor Oil, Ethoxylated is suitable for the production of semi-solid and liquid formulations of water-insoluble actives and other hydrophobic compounds.[1] Due to its emulsification functionality, it finds application in biological membrane- based drug transport studies.[6]

Other Notes

A derivative of castor oil and ethylene oxide.

Legal Information

Cremophor is a registered trademark of BASF SE

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

494.6 °F - Not applicable

Flash Point(C)

257 °C - Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL7415
BCCL7416
BCCM3065
BCCK9841
BCCJ9623

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Large-scale imaging of cortical network activity with calcium indicators.
Ikegaya Y
Neuroscience Research, 52, 132-132 (2005)
A nonionic polyethylene oxide (PEO) surfactant model: experimental and molecular dynamics studies of Kolliphor EL
Suys EJA, et al.
Journal of Pharmaceutical Sciences, 108(1), 193-204 (2019)
Triiodothyronine reverses depressed contractile performance after excessive catecholamine stimulation.
Timek T
The Annals of Thoracic Surgery, 66, 1618-1618 (1998)
Colloidal nanocarriers for the enhanced cutaneous delivery of naftifine: characterization studies and in vitro and in vivo evaluations
Erdal MS, et al.
International journal of nanomedicine, 11, 1027-1027 (2016)
Independent evaluation of the anatomical and behavioral effects of Taxol in rat models of spinal cord injury.
Popovich PG
Experimental Neurology, 261, 97-97 (2014)
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Questions

1–9 of 9 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Can this be stored in -20C?

    1 answer

    1. This product is to be stored at room temperature. Storing the product at freezer temperatures has not been evaluated and may cause degradation.

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  4. How much is the Cloud Point?

    1 answer

    1. The cloud point is not determined.

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  5. What is the hydrophile-lipophile balance (HLB) for Cremophor EL (Product No. C5135)?

    1 answer

    1. The manufacturer (BASF) reports an HLB value of between 12 and 14 for Cremophor EL (Product No. C5135).

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  6. What is the molecular weight of Cremophor EL (Product No. C5135)?

    1 answer

    1. The manufacturer (BASF) reports a molecular weight of approximately 2500 for Cremophor EL (Product No. C5135).

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  7. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  8. What solvents can I use to prepare a solution of Cremophor EL (Product No. C5135)? Or is it already in solution?

    1 answer

    1. Cremophor EL is a neat liquid, sold by weight. It is not already in solution. It is soluble in water; note that the solubility in water actually decreases with an increase in temperature. It is also soluble in many organic solvents, such as ethanol, isopropyl alcohol, chloroform and others.

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  9. How can Cremophor EL (Product No. C5135) be sterilized?

    1 answer

    1. The manufacturer (BASF) recommends that it be sterilized by heating in an autoclave for 30 minutes at 120°C. It may acquire a somewhat deeper color. Either the neat material or neutral aqueous solutions may be autoclaved.

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