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B6060

BVT.948

≥98% (HPLC), solid

Synonym(s):

4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione

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1 mg
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CHF 182.00
CHF 154.70

About This Item

Empirical Formula (Hill Notation):
C14H11NO3
CAS Number:
39674-97-0
Molecular Weight:
241.24
NACRES:
NA.77
PubChem Substance ID:
24724422
UNSPSC Code:
12352200
MDL number:
MFCD00616487
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, protect from light, under inert gas

CHF 154.70

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Quality Segment

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated, protect from light, under inert gas

color

red

solubility

DMSO: 18 mg/mL, H2O: insoluble

storage temp.

−20°C

SMILES string

CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12

InChI

1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3

InChI key

BAQXWJQSUXZVIP-UHFFFAOYSA-N

Biochem/physiol Actions

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.

Features and Benefits

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

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This Item
V4515L4170S8442
BVT.948 ≥98% (HPLC), solid

Sigma-Aldrich

B6060

BVT.948

VU0238429 solubility: ≥20 mg/mL in DMSO

Sigma-Aldrich

V4515

VU0238429

LDN-57444 ≥98% (HPLC)

Sigma-Aldrich

L4170

LDN-57444

SU 5416 ≥98% (HPLC)

Sigma-Aldrich

S8442

SU 5416

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

powder

form

solid

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage condition

desiccated, under inert gas, protect from light

storage condition

-

storage condition

desiccated, protect from light

storage condition

-

solubility

DMSO: 18 mg/mL, H2O: insoluble

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: 16 mg/mL

solubility

DMSO: 20 mg/mL, clear (warmed), H2O: insoluble

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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