Synthetic peptide directed towards the middle region of human CCPG1
Biochem/physiol Actions
CCPG1 acts as an assembly platform for Rho protein signaling complexes. It limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. It does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42. It may be involved in cell cycle regulation.
Sequence
Synthetic peptide located within the following region: TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKE
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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Liver international : official journal of the International Association for the Study of the Liver, 35(4), 1403-1415 (2014-08-08)
The molecular cochaperone CDC37 regulates the activities of multiple protein kinases, and is an attractive broad-spectrum target in many types of cancers in which it is over-expressed. This study investigates the antitumour effects of inhibiting CDC37 in human hepatocellular carcinoma
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