AV40278

Anti-FUS antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-FUS-CHOP, Anti-FUS1, Anti-Fusion (involved in t(12;16) in malignant liposarcoma), Anti-TLS
• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• mol wt: 53 kDa
• species reactivity: mouse, rabbit, rat, human, bovine
• concentration: 0.5 mg - 1 mg/mL
• technique(s): immunohistochemistry: suitable; western blot: suitable
• NCBI accession no.: NP_004951
• UniProt accession no.: P35637
• storage temp.: −20°C
• Gene Information: human ... FUS(2521)

Description

General description

Fused in sarcoma (FUS); translocated in LipoSarcoma (TLS) is a component of a fusion pro-oncogene resulting from a chromosomal translocation seen in liposarcomas. FUS/TLS belongs to a sub-family of RNA binding proteins that interacts with RNA, ssDNA, and dsDNA. FUS/TLS is involved in unique functions in mRNA processing and transport, transcriptional regulation and maintenance of genomic stability. FUsed in sarcoma (FUS); Translocated in LipoSarcoma (TLS) is a multifunctional protein implicated in a wide range of cellular processes, including transcription and mRNA processing, as well as in both cancer and neurological disease. Mutations in the fused in sarcoma (FUS) gene are linked to a form of familial amyotrophic lateral sclerosis (ALS), ALS6.

Specificity

Anti-FUS/TLS polyclonal antibody reacts with chicken, bovine, human, mouse, and rat FUsed in sarcoma/translocated in LipoSarcoma proteins.

Immunogen

The immunogen for anti-FUS antibody: synthetic peptide derected towards the N terminal of human FUS

Application

Anti-FUS/TLS polyclonal antibody is used to tag FUsed in sarcoma/translocated in LipoSarcoma proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the possible roles of FUsed in sarcoma/translocated in LipoSarcoma proteins in transcription and mRNA processing and amyotrophic lateral sclerosis, ALS6

Sequence

Synthetic peptide located within the following region: MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGY

Physical form

Lyophilized from PBS buffer with 2% sucrose

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable