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No, the product A2754 is not FDA approved for testing patient samples for platelet aggregation/function testing at this time.
A2754
Adenosine 5′-diphosphate sodium salt
bacterial, ≥95% (HPLC)
Synonym(s):
ADP sodium salt, ADP
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100 MG
CHF 34.50
500 MG
CHF 106.00
1 G
CHF 187.00
5 X 1 G
CHF 800.00
CHF 34.50
Estimated to ship on25 March 2025
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100 MG
CHF 34.50
500 MG
CHF 106.00
1 G
CHF 187.00
5 X 1 G
CHF 800.00
About This Item
Empirical Formula (Hill Notation):
C10H15N5O10P2
CAS Number:
Molecular Weight:
427.20
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51
CHF 34.50
Estimated to ship on25 March 2025
Recommended Products
biological source
bacterial
Quality Level
Assay
≥95% (HPLC)
form
powder
storage temp.
−20°C
SMILES string
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O
InChI
1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChI key
XTWYTFMLZFPYCI-KQYNXXCUSA-N
Gene Information
human ... HSP90AA1(3320) , P2RY1(5028)
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General description
Adenosine 5′-diphosphate (ADP) is an adenine nucleotide involved in energy storage and nucleic acid metabolism via its conversion into ATP by FOF1-ATP synthases. ADP can also be obtained by adenylate monophosphate (AMP) reaction catalyzed by adenylate kinase. ADP is a platelet agonist that is secreted from platelet dense granules. It promotes platelet activation through its interaction with ADP receptors P2Y1 and P2Y12. Upon conversion of ADP to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.
Application
Adenosine 5′-diphosphate sodium salt has been used:
- as a positive control of platelet aggregation to analyze antiplatelet activity of purified disintegrin by aggregometery.
- in the preparation of stock solution for a mito stress test.
- as a positive control in flow cytometry analysis to study the effect of pentameric C-reactive protein (pCRP) and monomeric CRP (mCRP) on the CD62p (P-selectin) expression of platelets.
- as a platelet agonist to stimulate platelet aggregation.[1]
Storage Class Code
11 - Combustible Solids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Protocols
ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.
HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.
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Is product A2754 FDA approved for use in testing patient samples (Platelet aggregation/function testing) at this time?
1 answer-
Helpful?
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I see that the molecular weight for Adenosine 5'-diphosphate (ADP) sodium salt, Product A2754, on the website does not include sodium, water and solvent content. Why is that?
1 answer-
The amount of sodium, water and solvent for ADP sodium salt will vary from lot to lot. The specific lot information can be found on the certificate of analysis located at our website. To obtain the "true" molecular weight (so that one can calculate the molarity of a solution), the sodium, water and solvent amount must be added to the molecular weight listed on the website.
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What are the spectral properties of Adenosine 5'-diphosphate (ADP) sodium salt, Product A2754?
1 answer-
The millimolar extinction coefficient of a pH 7 solution of ADP sodium salt is 15.4 at the absorbance maximum wavelength of 259 nm.
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What is the solubility of Adenosine 5'-diphosphate (ADP) sodium salt, Product A2754?
1 answer-
ADP sodium salt is soluble in water at a concentration of 50 mg/mL.
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What is the solution stability of Adenosine 5'-diphosphate (ADP) sodium salt, Product A2754?
1 answer-
ADP sodium salt is stable in solution for several months when stored at pH 7 and at -20 °C. When a solution is stored at pH 7 and 4 °C, the solution is stable for several days. It is unstable in acid.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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