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44521

Sigma-Aldrich

MTSEA Biotin

solubility: in DMSO, soluble

Synonym(s):

2-((Biotinoyl)amino)ethyl methanethiosulfonate, N-Biotinylaminoethyl methanethiosulfonate

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About This Item

Empirical Formula (Hill Notation):
C13H23N3O4S3
CAS Number:
162758-04-5
Molecular Weight:
381.53
MDL number:
MFCD01320376
UNSPSC Code:
12352200
PubChem Substance ID:
329756513

shelf life

limited shelf life, expiry date on the label

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

CS(=O)(=O)SCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12

InChI

1S/C13H23N3O4S3/c1-23(19,20)22-7-6-14-11(17)5-3-2-4-10-12-9(8-21-10)15-13(18)16-12/h9-10,12H,2-8H2,1H3,(H,14,17)(H2,15,16,18)/t9-,10-,12-/m0/s1

InChI key

CQPWMXNDGWWWHG-NHCYSSNCSA-N

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Application

MTSEA Biotin, a biotinylated methanethiosulfonate ethylamine reagent, is a thiol-reactive reagent used to label cysteine residues in proteins. MTSEA Biotin labeling is useful to study the structure, function and conformation of biomolecules such as transporters and enzymes.

Biochem/physiol Actions

Thiol-reactive reagent for labeling proteins at cysteine residues to study structure and function.

Certificates of Analysis (COA)

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Joachim Ramerstorfer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(3), 870-877 (2011-01-21)
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The Journal of biological chemistry, 287(21), 17801-17811 (2012-03-28)
In heterologous and endogenous expression systems, we studied the role of ERp44 and its complex partner endoplasmic reticulum (ER) oxidase 1-α (Ero1-Lα) in mechanisms regulating disulfide bond formation for serotonin transporter (SERT), an oligomeric glycoprotein. ERp44 is an ER lumenal
Ana M Pajor et al.
Biochimica et biophysica acta, 1808(6), 1454-1461 (2010-11-16)
Citric acid cycle intermediates, including succinate and citrate, are absorbed across the apical membrane by the NaDC1 Na+/dicarboxylate cotransporter located in the kidney and small intestine. The secondary structure model of NaDC1 contains 11 transmembrane helices (TM). TM7 was shown
M Traebert et al.
The Journal of membrane biology, 180(1), 83-90 (2001-04-04)
We have combined a functional assay, surface labeling and immunocytochemical methods to compare total and surface-exposed renal type IIa Na+/Pi cotransporter protein. The wild-type type cotransporter (NaPi-IIa) and its functionally comparable cysteine mutant S460C were expressed in Xenopus oocytes. S460C

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