11460
8-Azaxanthine monohydrate
≥98.0% (HPLC)
Synonym(s):
2,6-Dihydroxy-8-azapurine
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About This Item
Empirical Formula (Hill Notation):
C4H3N5O2 · H2O
CAS Number:
Molecular Weight:
171.11
Beilstein:
10424
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.25
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Quality Level
Assay
≥98.0% (HPLC)
form
solid
SMILES string
O.O=C1NC(=O)c2[nH]nnc2N1
InChI
1S/C4H3N5O2.H2O/c10-3-1-2(8-9-7-1)5-4(11)6-3;/h(H3,5,6,7,8,9,10,11);1H2
InChI key
VKEGPGRANAWNIN-UHFFFAOYSA-N
Application
8-Azaxanthine monohydrate has been used to determine the crystal and molecular structure of 1,3-dimethyl-8-azaxanthine (HDAX) monohydrate by X-ray diffraction.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Pascal Retailleau et al.
Acta crystallographica. Section D, Biological crystallography, 60(Pt 3), 453-462 (2004-03-03)
High-resolution X-ray structures of the complexes of Aspergillus flavus urate oxidase (Uox) with three inhibitors, 8-azaxanthin (AZA), 9-methyl uric acid (MUA) and oxonic acid (OXC), were determined in an orthorhombic space group (I222). In addition, the ligand-free enzyme was also
Paxton Forgue et al.
Journal of proteome research, 5(8), 1916-1923 (2006-08-08)
We describe a general protocol for using comparative NMR metabolomics data to infer in vivo efficacy, specificity and toxicity of chemical leads within a drug discovery program. The methodology is demonstrated using Aspergillus nidulans to monitor the activity of urate
L P Ribeiro
Biomedica biochimica acta, 47(2), 107-113 (1988-01-01)
Xanthine dehydrogenase (EC 1.2.1.37) activity was determined in the fat body of the Chagas' disease vector Triatoma infestans using a system in which phenazine methosulphate was associated with p-iodonitrotetrazolium violet as electron acceptors for the oxidation of the substrate xanthine.
Monika Budayova-Spano et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 62(Pt 3), 306-309 (2006-03-03)
Crystallization and preliminary neutron diffraction measurements of rasburicase, a recombinant urate oxidase enzyme expressed by a genetically modified Saccharomyces cerevisiae strain, complexed with a purine-type inhibitor (8-azaxanthin) are reported. Neutron Laue diffraction data were collected to 2.1 A resolution using
Nathalie Colloc'h et al.
Biochimica et biophysica acta, 1764(3), 391-397 (2006-02-16)
We report the three-dimensional structure determined by high-pressure macromolecular crystallography (HPMX) of a 135-kDa homo-tetrameric enzyme, urate oxidase from Aspergillus flavus complexed with its potent inhibitor 8-azaxanthin. Urate oxidase crystals are quite sensitive to pressure, as three-dimensional order is lost
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