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S2002

Sigma-Aldrich

Sodium azide

Sodium azide

ReagentPlus®, ≥99.5%

Synonym(s):

Hydrazoic acid sodium salt

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5 G
CHF 18.60
25 G
CHF 47.10
100 G
CHF 90.90
500 G
CHF 204.00
2 KG
CHF 776.00

CHF 18.60

Estimated to ship on27 March 2025

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5 G
CHF 18.60
25 G
CHF 47.10
100 G
CHF 90.90
500 G
CHF 204.00
2 KG
CHF 776.00

About This Item

Linear Formula:
NaN3
CAS Number:
26628-22-8
Molecular Weight:
65.01
EC Number:
247-852-1
MDL number:
MFCD00003536
UNSPSC Code:
12352201
PubChem Substance ID:
24899504
NACRES:
NA.21

CHF 18.60

Estimated to ship on27 March 2025

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biological source

synthetic (inorganic)

Quality Level

200

product line

ReagentPlus®

Assay

≥99.5%

form

powder

storage condition

(Tightly closed. Dry. Keep in a well-ventilated place. Do not store near acids.)

technique(s)

cell based assay: suitable
immunohistochemistry: suitable

color

white

mp

370-425 °C

solubility

soluble 65 g/L at 20 °C (completely)

suitability

suitable for chromatography
suitable for derivatization

application(s)

sample preparation

SMILES string

[Na]N=[N+]=[N-]

InChI

1S/N3.Na/c1-3-2;/q-1;+1

InChI key

PXIPVTKHYLBLMZ-UHFFFAOYSA-N

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General description

Sodium Azide (NaN3) is a potent inhibitor – a water-soluble crystalline powder that′s odorless. Widely recognized for its versatile applications, it plays a pivotal role across molecular biology, cell culture, and biochemical research. Sodium azide is commonly used as a bacteriostatic preservative in aqueous laboratory reagents and biological fluids. It is also a metabolic inhibitor, which inhibits oxidative phosphorylation. In cell culture, it maintains the integrity of your cell lines by preventing microbial contamination. Its application extends to molecular biology, where it aids in preserving nucleic acids for downstream analysis, ensuring the fidelity of your results.

Application

Baylis-Hillman acetates such as ethyl 2-(acetoxyphenylmethyl)acrylate can undergo nucleophilic displacement by sodium azide in aqueous medium to form ethyl (E)-2-azidomethyl-3-phenylpropenoate.[1]
Sodium azide is suitable for use in histopathology to prepare and store tissue samples.[2] [3] Also used as a component of staining buffer (HEPES buffer) for whole mount immunolabelling.[4]
Catalyst for:

  • Oxidative decarboxylation[5]
  • Michael addition reactions[6]

Reagent for synthesis of
  • Blue fluorescent copolymers[7]
  • Metal phosphonates[8]
  • Arenes via aminations[9]

Biochem/physiol Actions

Sodium azide is clinically used as a preservative in diluting fluid for counting red blood cells.[10] It prevents capping and internalization of fluorescent surface-bound antibodies in various scientific applications, including flow cytometry.[11]

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

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Signal Word

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral

Target Organs

Brain

Supplementary Hazards

EUH032

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB2097
STBJ2991
SDBB1087
SDBB0330
STBL3450

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Calcium uptake by rat kidney mitochondria.
DeLuca HF and Engstrom GW.
Proceedings of the National Academy of Sciences of the USA, 47(11), 1744-1750 (1961)
Nucleophilic displacement by azide and cyanide on Baylis-Hillman acetates in water.
Yadav JS, et al.
Tetrahedron Letters, 46(16), 2761-2763 (2005)
A critical review of published methods for analysis of red cell antigen-antibody reactions by flow cytometry, and approaches for resolving problems with red cell agglutination
Patricia A Arndt , George Garratty
Transfusion Medicine Reviews, 24(3), 174-192 (2010)
Abris Gilvesy et al.
Acta neuropathologica, 144(4), 651-676 (2022-08-31)
Tau pathology of the noradrenergic locus coeruleus (LC) is a hallmark of several age-related neurodegenerative disorders, including Alzheimer's disease. However, a comprehensive neuropathological examination of the LC is difficult due to its small size and rod-like shape. To investigate the
Three-dimensional cellular visualization in mouse apical periodontitis using combined whole-mount staining and optical tissue clearing
Kento Tazawa , Hajime Sasaki
Journal of oral biosciences, 65, 132-135 (2023)
View All Related Papers

Protocols

Antibody Purification using Protein A/G/L Agarose

Antibody purification protocols yield preparations containing endogenous IgG alongside specific antibodies.

ELISA Procedures

Detailed ELISA protocols cover indirect and capture ELISA techniques, recommending products for sandwich and indirect ELISA experiments.

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Questions

1–10 of 10 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. Can I use this product (S2002) for antibody storage? What is the differences between this idem and S8032-BioXtra or 71289-BioUltra? Thanks,

    1 answer

    1. Product S2002 has not been tested for antibody storage application, the suitability will have to be determined by the end user. Product S8032 and product 71289 are both research grade sodium azide with a quality level 200. Products with a quality level 200 are designed for non-regulated applications with limited change control requirements. The major difference between the two products are the product lines associated with them.

      Product S8032 falls into the BioXtra product line. These products consist of stringent testing protocols that may include trace metal analysis and specialized suitability testing, such as hybridoma or mouse embryo culture. This product is suitable for application-specific formulations.

      Product 71289 falls into the BioXtra product line. These products consist of the finest quality products for life science with the most stringent testing protocols and highest purity. These products undergo superior manufacturing methods and product specific testing protocols that are designed to ensure quality to the highest standard. The test may include, but are not limited to, purity by gel electrophoresis, trace metal testing, and application testing.

      Helpful?

  4. what do you mean by Bioxtra and reagentplus? How much difference are there between two grades.

    1 answer

    1. Products that fall under the BioXtra portfolio undergo stringent testing protocols that may include trace metal analysis and specialized suitability testing, such as hybridoma or mouse embryo culture. These products include application-specific formulations such as tablets and prepared solutions.

      Products that fall under the ReagentPlus portfolio are designed for general laboratory use and have purities that are greater or equal to 95%.

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  5. How can I determine the concentration of sodium azide in solution?

    1 answer

    1. Sodium azide forms a 3,5-dinitrobenzoyl derivative that can be quantified by liquid chromatography.  This method is reported in the Journal of Chromatography, 5, 597 (1982).

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  6. How stable are solutions of Product S2002, Sodium azide?

    1 answer

    1. At a neutral pH sodium azide solutions are fairly stable.  Under acidic conditions it is converted to hydrazoic acid, a volatile gas.

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  7. How does Product S2002, Sodium azide, inhibit certain metalloenzymes?

    1 answer

    1. The mechanism of sodium azide inhibition may be due to metal ion complexation and displacement from the enzyme.

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  8. What concentrations of Product S2002, Sodium azide, are used as a preservative?

    1 answer

    1. Typical concentrations for use are from 0.02 % to 0.1 %.

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  9. Are there any hazards associated with the disposal of Product S2002, Sodium azide?

    1 answer

    1. Sodium azide can form metal azides.  If you have metal pipes for your plumbing, you should not dispose of solutions down them.

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  10. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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