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Etofibrate

analytical standard

Synonym(s):

2-[(Pyridin-3-yl)carbonyloxy]ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, 3-Pyridinecarboxylic acid 2-[2-(4-chlorophenoxy)-2-methyl-1-oxopropoxy]ethyl ester

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About This Item

Empirical Formula (Hill Notation):
C18H18ClNO5
CAS Number:
31637-97-5
Molecular Weight:
363.79
Beilstein:
497931
EC Number:
250-743-1
MDL number:
MFCD00865727
UNSPSC Code:
41116107
PubChem Substance ID:
329769777
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O=C(OCCOC(C(C)(C)OC1=CC=C(Cl)C=C1)=O)C2=CC=CN=C2

InChI

1S/C18H18ClNO5/c1-18(2,25-15-7-5-14(19)6-8-15)17(22)24-11-10-23-16(21)13-4-3-9-20-12-13/h3-9,12H,10-11H2,1-2H3

InChI key

XXRVYAFBUDSLJX-UHFFFAOYSA-N

General description

Etofibrate (EF) is an ethylene glycol diester of clofibric and nicotinic acids. It is a cholesterol-lowering drug prescribed for treating hyperlipidaemias.

Application

Etofibrate may be used as an analytical reference standard for the determination of the analyte in plasma samples, pharmaceutical formulations, and environmental samples by analytical methods.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCC3104
BCBV6152
BCBQ2013V
BCBQ2013

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High performance liquid chromatographic determination of etofibrate and its hydrolysis products
El-Gindy A, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(1), 196-203 (2007)
Determination of 136 pharmaceuticals and hormones in sewage sludge using quick, easy, cheap, effective, rugged and safe extraction followed by analysis with liquid chromatography--time-of-flight-mass spectrometry
Peysson W and Vulliet E
Journal of Chromatography A, 1290(5), 46-61 (2013)
Pharmaceuticals in groundwaters: analytical methods and results of a monitoring program in Baden-W
Sacher F, et al.
Journal of Chromatography A, 938(1-2), 199-210 (2001)
Determination of etofibrate, fenofibrate, and atorvastatin in pharmaceutical preparations and plasma using differential pulse polarographic and square wave voltammetric techniques
Korany MA, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 91(5), 1051-1058 (2008)

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