G protein-coupled receptor kinases (GRK) are serine/threonine kinases that phosphorylate a variety of G-protein-coupled receptors (GPCRs), specifically activated forms, including adrenergic receptors, muscarinic acetylcholine receptors, dopamine receptors and opioid receptors. GRK receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation.
Specificity
This antibody recognizes the C-terminus of GRK. This antibody cross reacts with GRK6 (Prof. J. Trimmer, University of California, Davis.).
Immunogen
Epitope: C-terminus
Recombinant protein corresponding to the C-terminus of mouse Pan-GRK.
Application
Anti-Pan-GRK Antibody, clone N145/20 Cat. No. MABN615 is a highly specific mouse monoclonal antibody & that targets GRK & has been tested in western blotting.
Research Category Neuroscience
Research Sub Category Developmental Signaling
Quality
Evaluated by Western Blotting in mouse liver tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Pan-GRK in 10 µg of mouse liver tissue lysate.
Target description
~ 68 kDa observed
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control Mouse liver tissue lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
