CLN3 protein is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs).
Immunogen
KLH-conjugated linear peptide corresponding to human CLN3.
Application
Research Category Neuroscience
Research Sub Category Developmental Signaling
This Anti-CLN3 Antibody, Clone 2B8.2 is validated for use in Western Blotting and Immunohistochemistry for the detection of CLN3.
Western Blotting Analysis: 2.0 µg/mL from a representative lot detected CLN3 in 10 µg of A431 cell lysate. Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected CLN3 in rat cerebellum and human thalamus tissue.
Quality
Evaluated by Western Blotting in HepG2 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected CLN3 in 10 µg of HepG2 cell lysate.
Target description
~45 kDa observed. Uniprot describes 5 isoforms produced by alternative splicing at ~45, ~42, ~37, ~35, and ~28 kDa
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
