Dihydroorotate oxidase (DHODH) is also called Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase). DHODH is a member the dihydroorotate dehydrogenase (Type 2) family and is involved in pyrimidine biosynthesis. DHODH catalyzes the conversion of dihydroorotate to orotate using quinone as an electron acceptor. DHODH defects can cause postaxial acrofacial dysostosis (POADS).
Specificity
Other Homologies: Rat (93% sequence homology) and Mouse (86% sequence homology).
This antibody recognizes the Topological Domain (Mitochondrial intermembrane) of DHODH.
KLH-conjugated linear peptide corresponding to the Topological Domain (Mitochondrial intermembrane) of human DHODH.
Application
Anti-DHODH Antibody is a rabbit polyclonal antibody, validated for use in western blotting & IHC (Paraffin).
Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected DHODH in human testis and breast carcinoma sections.
Research Category Apoptosis & Cancer
Research Sub Category Apoptosis - Additional
Quality
Evaluated by Western Blotting in T47D cell lysate.
Western Blotting Analysis: 0.25 µg/mL of this antibody detected DHODH in 10 µg of T47D cell lysate.
Target description
~43 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control T47D cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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