AB15518

Anti-Neuronal pentraxin 1 Antibody

Chemicon^®, from rabbit

• Synonym(s): NPX1
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: mouse
• manufacturer/tradename: Chemicon^®
• technique(s): ELISA: suitable; immunohistochemistry: suitable; western blot: suitable
• NCBI accession no.: NM_002522.2
• UniProt accession no.: Q15818
• shipped in: dry ice
• target post-translational modification: unmodified
• Gene Information: human ... NPTX1(4884)

Description

General description

Neuronal Pentraxins: A new family of putative integral membrane pentraxins or Neuronal pentraxins identified through interaction with a presynaptic snake venom toxin taipoxin. NPX1, NPX2 and NPXR (Neuronal Pentraxin Receptor), the three neuronal pentraxins represent a novel neuronal uptake pathway that may function during synapse formation and remodeling. The N-terminal half of neuronal pentraxins are 20-30% identical to previously identified pentraxins (CRP and SAP), the three neuronal pentraxins are 50% identical to each other and are significantly larger than the classical pentraxins (>50 versus 30kDa), suggesting that they may have additional novel functions. NPX1(Neuronal Pentraxin 1) a 432aa protein in mouse and rat, 430aa in human (chr 17q25). It mediates the uptake of degraded synaptic material which could play an important role in synaptic remodeling, expressed in brain.

Specificity

Neuronal pentraxin 1 (NPX1).

The immunogen sequence is 94% conserved in rat, and 82% in human NPX1.

Immunogen

Synthetic peptide near the N-terminus of mouse NPX1

Application

Research Category
Neuroscience

Research Sub Category
Synapse & Synaptic Biology

This Anti-Neuronal pentraxin 1 Antibody is validated for use in ELISA, WB, IH for the detection of Neuronal pentraxin 1.

Western blot: 1-10 µg/mL using ECL.
Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 µg/mL
ELISA: 0.5-1 µg/mL using control peptide.
Optimal working dilutions must be determined by end user.

Physical form

ImmunoAffinity Purified

Liquid in PBS with 0.1% BSA.

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable