581011

Telomerase Inhibitor IX

The Telomerase Inhibitor IX, also referenced under CAS 368449-04-1, controls the biological activity of Telomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonym(s): Telomerase Inhibitor IX, MST-312, N,Nʹ-bis(2,3-Dihydroxybenzoyl)-1,3-phenylenediamine
• Empirical Formula (Hill Notation): C₂₀H₁₆N₂O₆
• CAS Number: 368449-04-1
• Molecular Weight: 380.35
• MDL number: MFCD24368986
• UNSPSC Code: 12352200
• NACRES: NA.54

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 5 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)
• InChI key: MIQUEZGHEJGPJB-UHFFFAOYSA-N

Description

General description

A cell-permeable, bis-catechol containing, m-phenylenediamide compound that displays anti-proliferative properties. Acts as a potent, reversible inhibitor of telomerase activity (IC₅₀ = 670 nM, TRAP lysate prepared from U937 cells). Prolonged treatment with MST-312 has been reported to result in telomere shortening and growth arrest in U937 cells. Does not inhibit the activity of Taq DNA polymerase (IC₅₀ >3 µM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
TRAP lysate prepared from U937 cells

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 670 nM against telomerase activity in TRAP lysate prepared from U937 cells

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Seimiya, H., et al. 2005. Cancer Cell7, 25.
Seimiya, H., et al. 2002. Mol. Cancer Ther.1, 657.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable