The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.
Synonym(s):
Granzyme B Inhibitor II, Caspase-8 Inhibitor I, Ac-IETD-CHO
A potent, reversible inhibitor of granzyme B and caspase-8 (Ki = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).
Potent, reversible granzyme B and caspase-8 inhibitor.
Biochem/physiol Actions
Cell permeable: no
Product does not compete with ATP.
Reversible: yes
Target Ki: 1 nM against caspase-8
Warning
Toxicity: Standard Handling (A)
Sequence
Ac-Ile-Glu-Thr-Asp-CHO
Other Notes
Gao, C.F., et al. 2001. Exp. Cell. Res.265, 145. Garcia-Calvo, M., et al. 1998. J. Biol. Chem.273, 32608. Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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