1.02330

Cellulose microcrystalline

for thin-layer chromatography

• Synonym(s): Cellulose microcrystalline
• Linear Formula: (C₆H₁₀O₅)_n
• CAS Number: 9004-34-6
• MDL number: MFCD00081512
• UNSPSC Code: 41115711
• EC Index Number: 232-674-9
• NACRES: NB.21

Properties

• material: cellulose matrix; plastic support
• Quality Level: 100
• form: microcrystalline
• autoignition temp.: 232 °C
• potency: >5000 mg/kg LD₅₀, oral (Rat); >2000 mg/kg LD₅₀, skin (Rabbit)
• feature: binder Organic Polymer; fluorescent indicator: no
• packaging: pkg of 500 g
• technique(s): thin layer chromatography (TLC): suitable
• particle size: 5-40 μm
• pore size: 60 Å medium pore diameter
• pH: 5-7.5 (20 °C, 100 g/L in H₂O, slurry)
• transition temp: flash point 260 °C
• density: 1.5 g/cm³ at 20 °C
• bulk density: 70‑400 kg/m³
• storage temp.: 2-30°C
• InChI: 1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3?,4?,5?,6?,7?,8?,9?,10-,11?,12+/m1/s1
• InChI key: GUBGYTABKSRVRQ-WFVLMXAXSA-N

Description

General description

Standardized sorbents ensure reliable results every time. Our broad spectrum meets all kinds of needs. In TLC, silica gel 60 sorbent is considered the most versatile. Our assortment of silica gel 60 features different grades with particle sizes ranging from 5-40 µm: silica with a gypsum binder, silica with no foreign binder, and silica gel with a fluorescence indicator. We also offer high-quality aluminum oxide, cellulose microcrystalline, and kieselgur (also known as diatomaceous earth).

Application

• Study of the influence of cellulose derivatives on physical and analytical attributes of a drug product belonging to BCS class II.: This research explored the impact of cellulose microcrystalline on the physical properties and analytical performance of a class II drug product. The findings demonstrated the role of cellulose microcrystalline in enhancing the stability and dissolution rate of the drug, contributing to improved bioavailability (Domoslawska et al., 2018).
• Application of ethyl cellulose, microcrystalline cellulose and octadecanol for wax based floating solid dispersion pellets.: The study investigated the use of microcrystalline cellulose in the formulation of wax-based floating pellets. The results highlighted its effectiveness in controlling the release profile and enhancing the floating properties of the drug delivery system (Yan et al., 2016).
• Modelling of porosity and waterfronts in cellulosic pellets for understanding drug release behavior.: This paper presented a model for analyzing the porosity and water penetration in cellulosic pellets, providing insights into the drug release mechanisms. The study emphasized the crucial role of microcrystalline cellulose in modulating drug release profiles (Gomez-Carracedo et al., 2010).
• Fast dissolving films made of maltodextrins.: The research explored the incorporation of microcrystalline cellulose in fast-dissolving films, demonstrating its impact on film integrity and dissolution rates. The findings support the use of microcrystalline cellulose in enhancing the performance of oral thin films (Cilurzo et al., 2008).
• Compressibility of floating pellets with verapamil hydrochloride coated with dispersion Kollicoat SR 30 D.: This study evaluated the compressibility and mechanical properties of floating pellets containing microcrystalline cellulose, showing its role in maintaining pellet integrity and controlled drug release (Sawicki & Lunio, 2005).

Analysis Note

d 10 (Laser diffraction, size distribution): 3.0 - 10.0 µm
d 50 (laser diffraction, size distribution): 10 - 30 µm
d 90 (Laser diffraction, size distribution): 30 - 60 µm

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable