1.00090

Adipic acid

EMPROVE^® ESSENTIAL, Ph. Eur., NF

• Synonym(s): Adipic acid, Hexanedioic acid
• Empirical Formula (Hill Notation): C₆H₁₀O₄
• CAS Number: 124-04-9
• Molecular Weight: 146.14
• MDL number: MFCD00004420
• UNSPSC Code: 12352106
• E Number: E355
• EC Index Number: 204-673-3

Properties

• Agency: NF; Ph. Eur.
• Quality Level: 500
• reg. compliance: FCC
• vapor pressure: 0.097 hPa ( 18.5 °C)
• description: EMPROVE^® ESSENTIAL Ph Eur,NF,FCC,E 355
• product line: EMPROVE^® ESSENTIAL
• form: solid
• autoignition temp.: 405 °C
• potency: 5700 mg/kg LD₅₀, oral (Rat); >7940 mg/kg LD₅₀, skin (Rabbit)
• technique(s): API processing | cocrystal formation: suitable; API processing | salt formation: suitable
• pH: 2.7 (25 °C, 23 g/L in H₂O)
• mp: 150.9 °C
• transition temp: flash point 196 °C
• solubility: 15 g/L
• density: 1.36 g/cm³ at 25 °C
• application(s): liquid formulation; pharmaceutical; solid formulation
• storage temp.: 15-25°C
• InChI: 1S/C6H10O4/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H,7,8)(H,9,10)
• InChI key: WNLRTRBMVRJNCN-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Adipic acid is typically used as a pH modifier in pharmaceutical applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H318
• Precautionary Statements: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 384.8 °F - closed cup
• Flash Point(C): 196 °C - closed cup