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07-324

Sigma-Aldrich

Anti-PP2A Antibody, C subunit

Upstate®, from rabbit

Synonym(s):

Anti-NEDLBA, Anti-PP2Ac, Anti-PP2CA, Anti-PP2Calpha, Anti-RP-C

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

bovine, rat, human, mouse

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_002715
NM_004156

UniProt accession no.

P67775

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PPP2CA(5515)

Specificity

PP2A catalytic subunit

Immunogen

peptide corresponding to amino acids 290-304 (DPAPRRGEPHVTRRT) of human PP2A

Application

Research Category
Signaling

Neuroscience
Research Sub Category
Oxidative Stress

Neurodegenerative Diseases
This Anti-PP2A Antibody, C subunit is validated for use in WB for the detection of PP2A.

Quality

routinely evaluated by immunoblot on RIPA lysates from mouse brain, heart, testes and spleen homogenates

Target description

36kDa

Physical form

0.2M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide, 5mg/ml BSA before the addition of glycerol to 30%
Immunoaffinity Chromatography

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Satoru Kake et al.
Scientific reports, 7(1), 4279-4279 (2017-06-29)
Canine mammary tumor is the most common neoplasm in female dogs, and it has generated considerable attention as a translational model for human breast cancer. Ser/Thr protein phosphatase 2A (PP2A) plays a critical role as a tumor suppressor, and SET/I2PP2A
Characterization of SET/I2PP2A isoforms in dogs.
Yabe, R; Fujiwara, N; Mizuno, T; Usui, T; Ohama, T; Sato, K
The Journal of Veterinary Medical Science null
Shunya Tsuji et al.
The Journal of veterinary medical science, 81(10), 1424-1430 (2019-09-19)
Osteosarcoma (OSA) is the most common bone tumor in dogs. Protein phosphatase 2A (PP2A), an evolutionary conserved serine/threonine protein phosphatase, is a crucial tumor suppressor. SET is a PP2A inhibitory protein that directly interacts with PP2A and suppresses its phosphatase
Rongbin Hu et al.
Plant, cell & environment, 40(1), 150-164 (2016-10-28)
Protein phosphatase 2A (PP2A) is an enzyme consisting of three subunits: a scaffolding A subunit, a regulatory B subunit and a catalytic C subunit. PP2As were shown to play diverse roles in eukaryotes. In this study, the function of the
Ha Yin Lee et al.
Science signaling, 11(512) (2018-01-11)
Cancer cells increase glucose metabolism to support aerobic glycolysis. However, only some cancer cells are acutely sensitive to glucose withdrawal, and the underlying mechanism of this selective sensitivity is unclear. We showed that glucose deprivation initiates a cell death pathway
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