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850546P

Avanti

MSDH

Avanti Research™ - A Croda Brand 850546P, powder

Synonym(s):

(S)-O-methyl-serine dodecylamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H35ClN2O2
CAS Number:
2074614-60-9
Molecular Weight:
322.91
UNSPSC Code:
12161902
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

mol wt

322.91 g/mol

packaging

pkg of 1 × 25 mg (850546P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850546P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[NH3+][C@@H](COC)C(NCCCCCCCCCCCC)=O.[Cl-]

General description

O-methyl-serine-dodecylamide hydrochloride (MSDH) is a synthetic lysosomotropic detergent.

Application

MSDH is suitable is suitable to induce lysosomal membrane destabilization to investigate the mechanistic basis for Bax/Bak-mediated autophagic cell death.

Biochem/physiol Actions

O-methyl-serine-dodecylamide hydrochloride (MSDH) stimulates cell death. After apoptosis, it may activate procaspase 3-like proteases and cause partial lysosomal rupture.

Packaging

5 mL Amber Glass Screw Cap Vial (850546P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Induction of cell death by the lysosomotropic detergent MSDH
Li W, et al.
Febs Letters, 470(1), 35-39 (2000)
Ana M Villamil Giraldo et al.
Langmuir : the ACS journal of surfaces and colloids, 32(50), 13566-13575 (2016-12-13)
Lysosomotropic detergents (LDs) selectively rupture lysosomal membranes through mechanisms that have yet to be characterized. A consensus view, currently, holds that LDs, which are weakly basic, diffuse across cellular membranes as monomers in an uncharged state, and via protonation in
Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
Karch J, et al.
eLife, 6, e30543-e30543 (2017)
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis
Fucho R, et al.
Journal of Hepatology, 61(5), 1126-1134 (2014)
Methylmercury and H2O2 provoke lysosomal damage in human astrocytoma D384 cells followed by apoptosis
Dare E, et al.
Free radical biology & medicine, 30(12), 1347-1356 (2001)

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