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699854P

Avanti

4A-MPLA (isomer C3)

Avanti Research™ - A Croda Brand

Synonym(s):

Monophosphopdyl Tetra-acyl Lipid A

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About This Item

Empirical Formula (Hill Notation):
C68H132N3O19P
CAS Number:
2260669-09-6
Molecular Weight:
1326.76
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (HPLC)

form

powder

packaging

pkg of 1 × 1 mg (699854P-1mg)
pkg of 1 × 5 mg (699854P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

application(s)

vaccine development

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO)[C@@H](OP([O-])(O)=O)[C@@H]1O)O[C@H](O)[C@@H]2NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H]2OC(C[C@H](O)CCCCCCCCCCC)=O.[NH4+]

Biochem/physiol Actions

Structural modification of diphosphoryl lipid A by hydrolysis produces MPLA (monophosphoryl lipid A) and is known to decrease its toxicity. MPLA, a lipopolysaccharide derivative, acts an immunomodulator and is non-toxic. For this reason, it is useful as a vaccine adjuvant. The MPLA induced immune response is tissue specific. It enhances host′s resistance against endotoxin induced effects. It also decreases cytokine production during infection.

Packaging

2 mL Amber Glass Crimp Cap Vial (699854P-1mg)
2 mL Amber Glass Crimp Cap Vial (699854P-5mg)

Other Notes

For R&D use only. Not for drug, household, or other uses.

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The cytokine response to lipopolysaccharide does not predict the host response to infection
Fensterheim BA, et al.
Journal of immunology (Baltimore, Md. : 1950), 198(8), 3264-3273 (2017)
Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through a TLR4-TRIF-PI3K signaling pathway
Watts III BA, et al.
American Journal of Physiology: Renal Physiology, 313(1), F103-F115 (2017)

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