Unless otherwise stated this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption or application to humans or animals.
H54409
trans-4-Hydroxy-L-proline
≥99%, for peptide synthesis
Synonym(s):
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp
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2.5 G
CHF 35.60
10 G
CHF 58.00
25 G
CHF 77.40
100 G
CHF 203.00
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2.5 G
CHF 35.60
10 G
CHF 58.00
25 G
CHF 77.40
100 G
CHF 203.00
About This Item
Empirical Formula (Hill Notation):
C5H9NO3
CAS Number:
Molecular Weight:
131.13
Beilstein:
81441
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Product Name
trans-4-Hydroxy-L-proline, ≥99%
Quality Level
Assay
≥99%
form
crystalline powder
optical activity
[α]25/D −75.6°, c = 1 in H2O
reaction suitability
reaction type: solution phase peptide synthesis
color
white to off-white
mp
273 °C (dec.) (lit.)
application(s)
peptide synthesis
SMILES string
O[C@H]1CN[C@@H](C1)C(O)=O
InChI
1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI key
PMMYEEVYMWASQN-DMTCNVIQSA-N
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General description
Trans-4-hydroxy-L-proline is an isomer of hydroxyproline used as a chiral building block in the production of many pharmaceuticals like neuroexcitatory kainoids.[1]
Application
Other Notes
Natural constituent of animal structural proteins such as collagen and elastin.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Tetrahedron Letters, 35, 6163-6163 (1994)
Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli
Yi Y, et al.
BMC biotechnology, 14, 1-8 (2014)
Tetrahedron, 49, 6195-6195 (1993)
Synthetic Communications, 23, 2691-2691 (1993)
Stefan de Vries et al.
Tissue engineering. Part A, 25(11-12), 830-841 (2018-05-10)
Notochordal cells (NCs) reside in the core of the healthy disc and produce soluble factors that can stimulate nucleus pulposus cells (NPCs). These NC-derived factors may be applied in intervertebral disc regeneration for treatment of low-back pain. However, identification of
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