Skip to Content
Merck
All Photos(2)

Documents

900715

Sigma-Aldrich

N-((S)-1-((4S,5S)-4-Benzyl-5-phenyl-4,5-dihydrooxazol-2-yl)-2,2-dimethylpropyl)acetamide

Synonym(s):

Chiral MPAO ligand

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C23H28N2O2
CAS Number:
2079094-32-7
Molecular Weight:
364.48
UNSPSC Code:
12161600
NACRES:
NA.22

Assay

≥95%

form

powder or crystals

reaction suitability

reaction type: C-C Bond Formation
reagent type: catalyst
reagent type: ligand
reaction type: C-H Activation

mp

130 °C

storage temp.

2-8°C

Application

N-((S)-1-((4S,5S)-4-Benzyl-5-phenyl-4,5-dihydrooxazol-2-yl)-2,2-dimethylpropyl)acetamide is a chiral ligand developed by Jin-Quan Yu′s lab for Pd(II)-catalyzed enantioselective β-C(sp3)H arylation, alkenylation, and alkynylation. This mono-protected aminomethyl oxazoline (MPAO) ligand was used in the challenging desymmetrization of isopropyl groups.

Other Notes

Formation of α-chiral centers by asymmetric β-C(sp3)–H arylation, alkenylation, and alkynylation

Hazard Statements

H413

Hazard Classifications

Aquatic Chronic 4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Related Content

Yu Group – Professor Product Portal

The Yu program centers around the discovery of catalytic carbon–carbon and carbon–heteroatom bond forming reactions based on C–H activation. Target transformations are selected to enable 1) the use of simple and abundant starting materials such as aliphatic acids, amines and alcohols, and 2) disconnections that drastically shorten the synthesis of a drug molecule or a major class of biologically active compounds.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service