237876
Trimethyl orthoacetate
99%
Synonym(s):
1,1,1-Trimethoxyethane
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100 ML
CHF 53.30
500 ML
CHF 166.00
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100 ML
CHF 53.30
500 ML
CHF 166.00
About This Item
Linear Formula:
CH3C(OCH3)3
CAS Number:
Molecular Weight:
120.15
Beilstein:
1098338
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
99%
form
liquid
refractive index
n20/D 1.388 (lit.)
bp
107-109 °C (lit.)
density
0.944 g/mL at 25 °C (lit.)
functional group
ether
SMILES string
COC(C)(OC)OC
InChI
1S/C5H12O3/c1-5(6-2,7-3)8-4/h1-4H3
InChI key
HDPNBNXLBDFELL-UHFFFAOYSA-N
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General description
Kinetics and mechanism of gas-phase elimination of trimethyl orthoacetate has been examined over the temperature range of 310-369°C and pressure range of 50-130Torr[1].
Trimethyl orthoacetate is used to synthesize acrylonitrile intermediates via reaction with alcohols followed by Knoevenagel condensation.[2]
Trimethyl orthoacetate is used to synthesize acrylonitrile intermediates via reaction with alcohols followed by Knoevenagel condensation.[2]
Application
Trimethyl orthoacetate has been used in the preparation of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-amino-9-(3-alkoxycarbonyl-oxymethyl-4-alkoxycarbonyloxybut -1-yl)purines[3].
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - Skin Sens. 1B
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Flash Point(F)
55.4 °F - closed cup
Flash Point(C)
13 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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A series of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purin es (1-8) and 2-amino-9-(3-alkoxycarbonyl-oxymethyl-4-alkoxycarbonyloxybut -1-yl)purines (9-12) were synthesized as potential prodrugs of penciclovir. Treatment of 6-deoxypenciclovir with trimethyl orthoacetate or triethyl orthopropionate (1.2 equiv) in DMF in the presence of p-TsOH.H2O (0.1 equiv) followed by quenching
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Tetrahedron Letters, 54, 1274-1278 (2013)
Edgar Márquez et al.
The journal of physical chemistry. A, 112(47), 12140-12142 (2008-11-01)
The gas-phase elimination kinetics of the title compounds have been examined over the temperature range of 310-369 degrees C and pressure range of 50-130 Torr. The reactions, in seasoned vessels, are homogeneous, unimolecular, and follow a first-order rate law. The
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