Sigma-Aldrich does not test saquinavir mesylate, product S8451, for solution stability. However, it is noted that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month. Whenever possible, solutions should be made up and used on the same day.
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S8451
Saquinavir -mesylat
≥98% (HPLC), powder
Synonym(e):
(2S)-N1[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-Dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide methanesulfonate, Ro-31-8959
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10 MG
CHF 97.30
50 MG
CHF 370.00
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10 MG
CHF 97.30
50 MG
CHF 370.00
About This Item
Empirische Formel (Hill-System):
C38H50N6O5·CH4O3S
CAS-Nummer:
Molekulargewicht:
766.95
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
Empfohlene Produkte
Assay
≥98% (HPLC)
Form
powder
Lagerbedingungen
desiccated
Farbe
white to tan
Löslichkeit
DMSO: ≥5 mg/mL
Ersteller
Roche
Lagertemp.
2-8°C
SMILES String
CS(O)(=O)=O.CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(N)=O)NC(=O)c4ccc5ccccc5n4
InChI
1S/C38H50N6O5.CH4O3S/c1-38(2,3)43-37(49)32-20-26-14-7-8-15-27(26)22-44(32)23-33(45)30(19-24-11-5-4-6-12-24)41-36(48)31(21-34(39)46)42-35(47)29-18-17-25-13-9-10-16-28(25)40-29;1-5(2,3)4/h4-6,9-13,16-18,26-27,30-33,45H,7-8,14-15,19-23H2,1-3H3,(H2,39,46)(H,41,48)(H,42,47)(H,43,49);1H3,(H,2,3,4)/t26-,27+,30-,31-,32-,33+;/m0./s1
InChIKey
IRHXGOXEBNJUSN-YOXDLBRISA-N
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Allgemeine Beschreibung
Saquinavir is a peptidomimetic hydroxyethylamine inhibitor, which is used to treat human immunodeficiency virus (HIV) infection.[1]
Anwendung
Saquinavir mesylate may be used in cell signaling and immunology studies.
Biochem./physiol. Wirkung
Saquinavir is an HIV Protease Inhibitor used in antiretroviral therapy.
Saquinavir is an HIV Protease Inhibitor used in antiretroviral therapy. It inhibits both HIV-1 and HIV-2 proteases. Studies have also looked at saquinavir as a possible anti-cancer agent.
Leistungsmerkmale und Vorteile
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Yung-Chih Kuo et al.
Colloids and surfaces. B, Biointerfaces, 101, 101-105 (2012-07-17)
Application of cationic solid lipid nanoparticles (CSLNs), comprising complex internal matrix and lipid-regulated external surface, is an intriguing issue in current bionanotechnology. This study presents dissolution kinetics of saquinavir (SQV) from CSLNs with cholesterol-mediated esterquat 1 (EQ 1) and biocompatibility
Zhenmin Liang
Bioanalysis, 4(10), 1227-1234 (2012-06-02)
Ionization matrix effects are one of the most difficult issues in LC-MS bioanalysis that are without a good and universal solution. Most people in the field are aware of it, but some are not sure how to deal with it.
Atsuko Tomaru et al.
Drug metabolism and pharmacokinetics, 30(3), 221-226 (2015-04-18)
Modulation of CYP3A and/or P-gp function by several excipients has been reported. However, relatively few studies have investigated their effects in humans. Therefore, the aim of this clinical study was to clarify the effects of Cremophor EL on the inhibition
Shigeyoshi Harada et al.
The Journal of general virology, 94(Pt 5), 933-943 (2013-01-05)
The initiation of drug therapy results in a reduction in the human immunodeficiency virus type 1 (HIV-1) population, which represents a potential genetic bottleneck. The effect of this drug-induced genetic bottleneck on the population dynamics of the envelope (Env) regions
Marija Mojic et al.
Molecular pharmacology, 82(4), 700-710 (2012-07-17)
We have examined the influence of the nitric oxide (NO)-modified anti-inflammatory drug (S,R)-3-phenyl-4,5-dihydro-5-isoxasole acetic acid (VGX-1027) named GIT-27NO or the NO-modified antiviral drug saquinavir (Saq) named Saq-NO on two colon cancer cell lines, mouse CT26CL25 and human HCT116. The effects
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Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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What is the solution stability of Saquinavir mesylate, product S8451?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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