S3699

Anti-SEL1L (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-SEL1-like, Anti-Sel-1 suppressor of lin-12-like (C. elegans), Anti-Suppressor of lin-12-like
• NACRES: NA.41
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IF, IP, WB
• Citations: 17

Eigenschaften

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~100 kDa
• species reactivity: human
• concentration: ~1.0 mg/mL
• technique(s): immunoprecipitation (IP): 2-5 μg using lysate of human MCF-7 cells, indirect immunofluorescence: 2-4 μg/mL, western blot: 0.5-1.0 μg/mL using whole extracts of human MCF-7 cells
• UniProt accession no.: Q9UBV2
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SEL1L(6400)

Beschreibung

General description

SEL1L (Sel-1-like) is a type I transmembrane glycoprotein, that is located in ER (endoplasmic reticulum). It is considered as a putative tumor suppressor gene. It is located on chromosome 14q.

SEL1L is highly expressed in the pancreas.

Application

Anti-SEL1L (N-terminal) antibody produced in rabbit has been used in

• immunoblotting
• immunoprecipitation
• immunofluorescence

Biochem/physiol Actions

SEL1L (Sel-1-like) participates in the degradation pathway linked with endoplasmic reticulum (ER), malignant transformation and stem cells. It helps in the self regeneration of the neural stem cell. It controls cell fate developmental decision and homeostasis. It plays an important role in retaining homeostasis of endoplasmic reticulum throughout embryonic growth of vertebrate.

SEL1L is involved in cell growth and cancer progression.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)