P9256

Psychosine from bovine brain

lyophilized powder, ≥98% (HPLC)

• Synonym(e): 1-β-D-Galactosylsphingosine
• Empirische Formel (Hill-System): C₂₄H₄₇NO₇
• CAS-Nummer: 2238-90-6
• Molekulargewicht: 461.63
• NACRES: NA.77
• PubChem Substance ID: 24899021
• UNSPSC Code: 12352211
• MDL number: MFCD00057505
• Assay: ≥98% (HPLC)
• Form: lyophilized powder

Eigenschaften

• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: lyophilized powder
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O
• InChI: 1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18-,19+,20+,21-,22-,23+,24+/m0/s1
• InChI key: HHJTWTPUPVQKNA-PIIMIWFASA-N

Beschreibung

Application

Psychosine has been used as a lipid in lipid-protein overlay binding assay.

Biochem/physiol Actions

Psychosine is a neurotoxic lysosphingolipid and a glycolipid precursor for the synthesis of cerebrosides. It is synthesized from galactosylceramide, phrenosin. Elevated psychosine levels are implicated in Krabbe disease. It mediates demyelination and consequently oligodendrocytes degeneration. Psychosine is also correlated to neurological disease, Globoid cell leukodystrophy (GLD), where in galactosylceramidase (GALC) enzyme deficiency leads to its accumulation.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves