P4484

Purvalanol A

≥98% (HPLC), powder

• Synonym(e): 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-60
• Empirische Formel (Hill-System): C₁₉H₂₅ClN₆O
• CAS-Nummer: 212844-53-6
• Molekulargewicht: 388.89
• NACRES: NA.77
• PubChem Substance ID: 24898543
• UNSPSC Code: 12352200
• MDL number: MFCD02179211
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• solubility: methylene chloride: 50 mg/mL
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c3ncn(C(C)C)c3n1
• InChI: 1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
• InChI key: PMXCMJLOPOFPBT-HNNXBMFYSA-N

Beschreibung

Biochem/physiol Actions

Purvalanol A is found to inhibit ABCG2 (ATP-binding cassette G2) transporter in vitro. It is also known to attenuate cellular Src kinase action and induce cell cycle arrest at the G2 to M phase transition.

Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)