N6909

Neurturin human

>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

• Synonym(e): NRTN, NTN
• MDL-Nummer: MFCD01867712
• UNSPSC-Code: 51111800

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in E. coli
• Assay: >95% (SDS-PAGE)
• Form: lyophilized powder
• Wirksamkeit: 15-50 ng/mL ED₅₀
• Mol-Gew.: monomer calculated mol wt ~12.5 kDa; predicted mol wt ~14 kDa by SDS-PAGE (reducing)
• Lagerbedingungen: avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
• Verunreinigungen: endotoxin, tested
• UniProt-Hinterlegungsnummer: Q99748
• Lagertemp.: −20°C
• Angaben zum Gen: human ... NRTN(4902)

Beschreibung

Biochem./physiol. Wirkung

Member of the glial cell line-derived neurotrophic factor family of ligands. Exerts potent effects on the function and survival of central and peripheral neurons. Activates the RET receptor tyrosine kinase, MAP kinase, and phosphatidylinositol 3-kinase pathways. Human and mouse NTN share 91% sequence identity.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.

Hinweis zur Analyse

The biological activity is measured by its ability to bind recombinant human GFRα2/Fc.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)