M4603
Acetyl-[Nle4, Asp5, D-2-Nal7, Lys10]-cyclo-α-Melanocyte Stimulating Hormone Amide Fragment 4-10
≥95% (HPLC)
Synonym(e):
SHU9119
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1 MG
CHF 427.00
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1 MG
CHF 427.00
About This Item
Empirische Formel (Hill-System):
C54H71N15O9
Molekulargewicht:
1074.24
MDL-Nummer:
UNSPSC-Code:
51111800
NACRES:
NA.32
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Amino Acid Sequence
Ac-Nle-cyclo(Asp-His-Nal-Arg-Trp-Lys-NH2)
Biochem./physiol. Wirkung
Screening analogs of the cyclic lactam melanocortin agonist MTII led to the identification of the agoutimimetic SHU9119. This compound shares pharmacological properties with the agouti peptide in that it is a potent antagonist of the melanocortin-4 receptor and a less potent antagonist of the melanocortin-3 receptor.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Anna Fosch et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown adipose tissue (BAT) axis and the underlying mechanisms have remained largely
V J Hruby et al.
Journal of medicinal chemistry, 38(18), 3454-3461 (1995-09-01)
The cloning of the melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) receptors (MC1-R and MC2-R, respectively) recently has led to the identification of three additional melanocortin receptors, MC3-R, MC4-R, and MC5-R. The MC2 receptor primarily recognizes only ACTH peptides, but
W Fan et al.
Nature, 385(6612), 165-168 (1997-01-09)
Dominant alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a consequence of ectopic expression of the agouti peptide. This peptide, normally only found in the skin, is a high-affinity antagonist of the melanocyte-stimulating hormone
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