E7278

Anti-S1P₂, C-Terminal antibody produced in rabbit

~1 mg/mL, fractionated antiserum, buffered aqueous solution

• Synonym(e): Anti-EDG-5, Anti-Endothelial Cell Differentiation Gene 5
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD02686109
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 3

Eigenschaften

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: fractionated antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~42 kDa by SDS-PAGE
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): western blot: suitable
• UniProt accession no.: O95136
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... S1PR2(9294)

Beschreibung

Immunogen

synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-5/S1P₂ receptor.

Application

Anti-S1P₂, C-Terminal antibody produced in rabbit is suitable for western blotting.

Biochem/physiol Actions

Sphingosine-1-phosphate receptor 2 (S1PR2 or S1P2) is a human gene encodeing a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P) and regulates vascular permeability along with S1P1. Activation of S1P2R in endothelial cells increases vascular permeability. It is a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses. S1P acts as an intercellular mediator by interacting with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. S1P2 receptor is involved in S1P-induced platelet aggregation and Rho kinase activation. Type 2 diabetes patient responds to S1P.

Physical form

Supplied in phosphate buffered saline, pH 7.3, containing 0.08% sodium azide.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids