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Wichtige Dokumente

E1408

Sigma-Aldrich

14-3-3 Eta histidine-tagged human

recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(e):

14-3-3η, 14-3-3F, 14-3-3e, MGC93547, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide, YWHAH, Ywha1

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About This Item

UNSPSC-Code:
12352200

Rekombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

Form

buffered aqueous glycerol solution

Mol-Gew.

~30 kDa (14-3-3 proteins)

Versandbedingung

dry ice

Lagertemp.

−20°C

Angaben zum Gen

human ... LOC646954(646954)

Biochem./physiol. Wirkung

14-3-3 proteins are involved in a multitude of biological processes and play a regulatory role in processes such as apoptotic cell death, mitogenic signal transduction, and cell cycle control. 14-3-3η binds various proteins such as the MTLX-2 transcription factor as well as the DNA binding domain of Miz1 transcription factor. 14-3-3η also binds the glucocorticoid receptor, functioning as a positive regulator in the glucocorticoid signaling pathway. 14-3-3η is expressed and regulated in nerve cells.

Physikalische Form

Supplied as a 0.2 μm filtered solution in 50 mM Tris-HCl, pH 7.6, 1 mM EDTA, 1 mM DTT, and 20% glycerol (w/v).

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

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S J Tang et al.
The Journal of biological chemistry, 273(39), 25356-25363 (1998-09-17)
Homeodomain proteins play important roles in various developmental processes, and their functions are modulated by polypeptide cofactors. Here we report that both in vitro and in vivo, 14-3-3eta is associated with the TLX-2 homeodomain transcription factor that is required for
Yoon Suk Kim et al.
Endocrinology, 146(7), 3133-3140 (2005-03-26)
The glucocorticoid receptor (GR), a member of the nuclear receptor superfamily, mediates the effects of glucocorticoids. It is known that 14-3-3 family proteins interact with GR and regulate its transcriptional activity. They also bind to several molecules and influence many
Michael Wanzel et al.
Nature cell biology, 7(1), 30-41 (2004-12-08)
The transcription factor Miz1 is required for DNA-damage-induced cell-cycle arrest. We have now identified 14-3-3eta as a gene that inhibits Miz1 function through interaction with its DNA binding domain. Binding of 14-3-3eta to Miz1 depends on phosphorylation by Akt and
14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation.
Guri Tzivion et al.
The Journal of biological chemistry, 277(5), 3061-3064 (2001-11-16)
José M A Moreira et al.
Molecular & cellular proteomics : MCP, 7(7), 1225-1240 (2008-04-02)
The 14-3-3 proteins constitute a family of highly conserved and broadly expressed multifunctional polypeptides that are involved in a variety of important cellular processes that include cell cycle progression, growth, differentiation, and apoptosis. Although the exact cellular function(s) of 14-3-3

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