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D0565

Sigma-Aldrich

Digoxin-BSA bovine

lyophilized powder

Synonym(e):

Digoxin-BSA

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About This Item

MDL-Nummer:
MFCD01323187
UNSPSC-Code:
12352202
NACRES:
NA.25

Biologische Quelle

bovine

Form

lyophilized powder

Kennzeichnungsgrad

~10 mol Digoxin per mol albumin

Methode(n)

inhibition assay: suitable

UniProt-Hinterlegungsnummer

P02769

Lagertemp.

2-8°C

Angaben zum Gen

cow ... ALB(280717)

Anwendung

Digoxin-BSA bovine is a cardioactive glycoside which can increase intracellular calcium concentration through Na+/K+-ATPase pump inhibition. Digoxin has been used in treatments of heart related disease and also studies of cancer treatments. It has shown the ability to inhibit prostate cancer cell growth, but has also shown a reduction in the efficiency of chemotherapy (reduced drug absorption) by increasing the amount of P-glycoprotein (Pgp).

Biochem./physiol. Wirkung

Antigen-protein conjugate.

Physikalische Form

Lyophilized from 0.06 M Tris

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Chiara Riganti et al.
Toxicology and applied pharmacology, 240(3), 385-392 (2009-08-04)
Digoxin and ouabain are cardioactive glycosides, which inhibit the Na+/K+-ATPase pump and in this way they increase the intracellular concentration of cytosolic calcium ([Ca2+](i)). They are also strong inducers of the P-glycoprotein (Pgp), a transmembrane transporter which extrudes several drugs
S P O'Neill et al.
Journal of immunology (Baltimore, Md. : 1950), 116(2), 363-366 (1976-02-01)
Animals immunized with hapten-protein conjugates subsequently circulate high concentrations of hapten bound by antibody. The levels of hapten detected are capable of significantly reducing antibody titer in the sera immunized animals. In the case of steroid-protein conjugates, the main source
Elizabeth A Platz et al.
Cancer discovery, 1(1), 68-77 (2011-12-06)
Identification of novel indications for commonly prescribed drugs could accelerate translation of therapies. We investigated whether any clinically-used drugs might have utility for treating prostate cancer by coupling an efficient, high-throughput laboratory-based screen and a large, prospective cohort study. In
Y Ikeda et al.
Biological & pharmaceutical bulletin, 23(8), 906-910 (2000-08-30)
The preparation and antigenic properties of digoxin C-3' and C-3" hemisuccinate-bovine serum albumin (BSA) conjugates are described. The antisera were prepared by immunizing rabbits with each of the digoxin-BSA conjugates, and properties of the antisera were characterized by RIA with
Ioannis Prassas et al.
Molecular cancer therapeutics, 10(11), 2083-2093 (2011-08-24)
Cardiac glycosides (e.g., digoxin, digitoxin) constitute a diverse family of plant-derived sodium pump inhibitors that have been in clinical use for the treatment of heart-related diseases (congestive heart failure, atrial arrhythmia) for many years. Recently though, accumulating in vitro and

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