C9873

CPTH2

≥98% (HPLC), powder

• Synonym(e): Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone
• Empirische Formel (Hill-System): C₁₄H₁₄ClN₃S
• CAS-Nummer: 357649-93-5
• Molekulargewicht: 291.80
• NACRES: NA.77
• PubChem Substance ID: 329775211
• UNSPSC Code: 12352200
• MDL number: MFCD02307488
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100

Eigenschaften

• InChI key: YYTHPXHGWSAKIZ-UHFFFAOYSA-N
• SMILES string: Clc1ccc(cc1)-c2csc(N\N=C3\CCCC3)n2
• InChI: 1S/C14H14ClN3S/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12/h5-9H,1-4H2,(H,16,18)
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• Quality Level: 100

Beschreibung

General description

CPTH2 ((3-methylcyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone)) inhibits histone acetyltransferase functionality and reduces acetylation of histone H3 [1] and H4.[2] CPTH2 promotes apoptosis in lymphoma cell lines.[2] It may serve as an anticancer agent. CPTH2 inhibits α-tubulin acetylation and modulates autophagic pathway in human acute myeloid leukemia cell lines.[3]

Application

CPTH2 has been used for the inhibition of histone acetyltransferase in cortical cultures,[4] bud cells[5] and natural killer T cells (iNKT).[6]

Biochem/physiol Actions

CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network.

CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. Histone acetyltransferases (HATs) act as transcriptional coactivators. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable