C5688

Complement factor D from human plasma

90-110 μg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)

• CAS-Nummer: 37213-56-2
• MDL-Nummer: MFCD00166417
• UNSPSC-Code: 12352202
• NACRES: NA.61

Eigenschaften

• Biologische Quelle: human plasma
• Qualitätsniveau: 200
• Assay: ≥90% (SDS-PAGE)
• Form: liquid
• Konzentration: 90-110 μg/mL in PBS, pH 7.2
• UniProt-Hinterlegungsnummer: P00746
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... CFD(1675)

Beschreibung

Anwendung

Complement factor D is a serine protease essential for the activation of the alternative pathway in the complement system. Research of complement factor D has revealed that a self inhibitory loop is responsible for switch from a resting to active state. Additionally, recent research has linked a complement factor D gene, single nucleotide polymorphism (SNP) rs3826945, with age-related macular degeneration (AMD). In these AMD cases there was a significant increase in plasma complement factor D concentration, even though previous research has shown no association between complement factor D SNP genes and AMD.

Biochem./physiol. Wirkung

Complement factor D is a serine protease with structural homologies with chymotrypsin. In the complement cascade, factor D cleaves complement factor B in complex with activated complement component C3. It is identical to adipsin, which is expressed in adipose tissue.

Hinweis zur Analyse

Source plasma tested for HBSAg, HCV, HBC, syphillis, and HIV-1/HIV-2

Sonstige Hinweise

View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer

Haftungsausschluss

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable