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C0884

Coenzym B12

≥97.0%

Synonym(e):

5′-Deoxyadenosylcobalamin, Adenosylcobalamin, Cobamamid, DMBC-Coenzym

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Über diesen Artikel

Empirische Formel (Hill-System):
C72H100CoN18O17P
CAS-Nummer:
Molekulargewicht:
1579.58
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
EC Number:
237-627-6
Beilstein/REAXYS Number:
4122932
MDL number:
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Quality Segment

assay

≥97.0%

form

powder and chunks

technique(s)

HPLC: suitable

color

red to very dark red, very dark red-brown

storage temp.

−20°C

SMILES string

CC(CNC(=O)CCC1(C)C(CC(N)=O)C2N([Co+]C[C@H]3O[C@@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)C1=C(C)C6=NC(=CC7=NC(=C(C)C8=NC2(C)C(C)(CC(N)=O)C8CCC(N)=O)C(C)(CC(N)=O)C7CCC(N)=O)C(C)(C)C6CCC(N)=O)OP([O-])(=O)O[C@H]9[C@@H](O)[C@H](O[C@@H]9CO)n%10cnc%11cc(C)c(C)cc%10%11

InChI

1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-2/t31?,34?,35?,36?,37?,41-,52-,53-,56?,57+,59?,60?,61?,62?;4-,6-,7-,10+;/m11./s1

InChI key

ZIHHMGTYZOSFRC-PMDPKNCCSA-L

General description

Vitamin B12 Cobalamin bezieht sich auf eine Gruppe chemisch-verwandter kobalthaltiger Moleküle. Die physiologisch aktiven Formen von Vitamin B12 umfassen Methylcobalamin und Adenosylcobalamin, während Hydroxocobalamin (Vitamin B12a, OHCbl) und Cyanocobalamin (CNCbl) Speicher- und Darreichungsformen sind.

Application

Coenzym B12 wurde als Zusatz bei der Kultivierung von Plasmidvarianten in einem In-vivo-Assay von yvrC-lacZ-Fusionen verwendet.

Biochem/physiol Actions

Vitamin B12 Cobalamin ist an der DNA-Synthese und Fettsäuresynthese beteiligt. Es spielt auch eine wichtige Rolle als Coenzym bei der Umwandlung von mitochondrialem Methylmalonyl-Coenzym A zu Succinyl-Coenzym A.

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Dieser Artikel
M9756H8017C3607
technique(s)

HPLC: suitable

technique(s)

HPLC: suitable

technique(s)

HPLC: suitable

technique(s)

-

assay

≥97.0%

assay

≥97%

assay

≥95% (HPLC)

assay

96.0-102.0% dry basis

form

powder and chunks

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

color

red to very dark red, very dark red-brown

color

red to very dark red

color

red to brown

color

dark red


Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the pH stability of adenosylcobalamine?

    1 answer
    1. The pH stability of this product in solution has not been determined.

      Helpful?

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